Yi Hung Li

6395514, May 28, 2002

Nov 18, 1998

09/195106

Ying-Fei Wei - San Mateo CA
Yi Li - Sunnyvale CA
Jian Ni - Rockville MD
Craig A. Rosen - Laytonsville MD
Steven M. Ruben - Olney MD

Human Genome Sciences, Inc. - Rockville MD

C12N 510

435 695, 435 711, 435 712, 435471, 4353201, 435325, 4352523, 43525411, 536 231, 536 235, 530351, 424 851

The present invention relates to a novel CK-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK-5 protein. CK-5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

6518404, Feb 11, 2003

Mar 7, 2000

09/520210

Yi Li - Sunnyvale CA
Craig A. Rosen - Laytonsville MD
Chandrika Kumar - West Windsor NJ

Human Genome Sciences, Inc. - Rockville MD
Smithkline Beecham Corp. - Philadelphia PA

C07K 1628

5303879, 5303881, 5303871, 5303873, 53038815, 5303891

A human endothelin-bombesin receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for disclosed. Also disclosed are methods for utilizing such polypeptide for identifying agonists and antagonists to such polypeptide. Agonists to the endothelin-bombesin receptor polypeptide of the present invention may be used to treat asthma, Parkinsons Disease, acute heart failure, hypotension and osteoporosis. Antagonists against such polypeptides may be used therapeutically to treat hypertension, ulcerigenesis, subarachnoid hemorrhage, asthma, tumors, ciclosporin toxicity, cancer and septic shock. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.

6887683, May 3, 2005

Mar 3, 2000

09/518383

Yi Li - Sunnyvale CA, US
Steven M. Ruben - Olney MD, US

Human Genome Sciences, Inc. - Rockville MD

C12N005/10
C12N015/12
C12N015/63

435 691, 435 711, 435 712, 435 697, 435325, 4352523, 43525411, 4353201, 435471

Two human G-Protein coupled receptor polypeptides and DNA (RNA) encoding each of such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the nucleic acid sequence of each of the G-protein coupled receptors.

7060261, Jun 13, 2006

Apr 3, 2002

10/114482

Ying-Fei Wei - Berkeley CA, US
Yi Li - Sunnyvale CA, US
Jian Ni - Germantown MD, US
Craig A. Rosen - Laytonsville MD, US
Steven M. Ruben - Olney MD, US

Human Genome Sciences, Inc. - Rockville MD

C07K 14/52
C12N 15/63
C12N 5/10
A61K 38/19

424 851, 530351, 530402, 435 695, 435 697, 435 711, 435 712, 435471, 4353201, 4352523, 43525411, 435325

The present invention relates to a novel CKα-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-5 protein. CKα-5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CKα-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

7160546, Jan 9, 2007

Sep 3, 2002

10/232686

Yi Li - Sunnyvale CA, US
Steven M Ruben - Olney MD, US

Human Genome Sciences, Inc. - Rockville MD

A61K 39/00

4241851, 435325, 435326, 5303871

Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

7320869, Jan 22, 2008

Sep 13, 2005

11/224076

Ying-Fei Wei - Berkeley CA, US
Yi Li - Sunnyvale CA, US
Jian Ni - Germantown MD, US
Craig A. Rosen - Laytonsville MD, US
Steven M. Ruben - Brookeville MD, US

Human Genome Sciences, Inc. - Rockville MD

G01N 33/53
C12N 5/12
C07K 16/24

435 71, 435326, 5303871, 5303879, 5303881, 5303873

The present invention relates to a novel CKα-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-5 protein. CKα-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and fragments thereof that specifically bind to CKα-5 polypeptides are also disclosed, as are compositions and methods for making such antibodies. The invention further relates to screening methods for identifying agonists and antagonists of CKα-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

7547114, Jun 16, 2009

Jul 30, 2007

11/830311

Yi Li - Pleasanton CA, US
Li Xu - Saratoga CA, US

YLX Corp. - San Jose CA

F21V 9/00

362231, 362293, 362555, 362583, 362284, 362324, 353 20, 353 31

A multicolor illumination device using an excitation light source and a multi-segmented moving plate with wavelength conversion materials (e. g. phosphors) is disclosed. The exciting light source is a light emitting diode or a laser diode emitting in the UV and/or blue region. The wavelength conversion materials absorb the excitation light and emit longer wavelength light. Each segment of the moving plate contains a different wavelength conversion material or no wavelength conversion material. The plate is supported to move so that different segments are exposed to the excitation light at different times. The plate may be a wheel or rectangular in shape and rotates or oscillates linearly. When the plate moves, light of different colors is generated sequentially in time by the different wavelength conversion materials in different segments of the plate. The multicolor illumination device may be used in a projector system having a microdisplay imager for image display.

7888466, Feb 15, 2011

Apr 11, 2003

10/411284

Yi Li - Sunnyvale CA, US

Human Genome Sciences, Inc. - Rockville MD

C07K 14/00
C07H 21/04
C12N 15/00
C12P 21/00

530350, 536 231, 435 695, 435 701

Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.