Inventors:
Benny Askew - Newbury Park CA, US
Jeffrey Adams - Thousand Oaks CA, US
Shon Booker - Thousand Oaks CA, US
Guoqing Chen - Thousand Oaks CA, US
Lucian V. DiPietro - Gloucester MA, US
Daniel Elbaum - Newton MA, US
Julie Germain - Medford MA, US
Stephanie D. Geuns-Meyer - Medford MA, US
Gregory J. Habgood - Merrimac MA, US
Michael Handley - Greenbrae CA, US
Qi Huang - Moorpark CA, US
Aiwen Li - Westlake Village CA, US
Nobuko Nishimura - West Hills CA, US
Rana Nomak - Istanbul, TR
Vinod F. Patel - Acton MA, US
Babak Riahi - Woodland Hills CA, US
Joseph L. Kim - Wayland MA, US
Ning Xi - Thousand Oaks CA, US
Kevin Yang - San Gabriel CA, US
Chester Chenguang Yuan - Newbury Park CA, US
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
A61K031/4427
C07D401/12
US Classification:
514256, 514300, 514314, 514333, 514336, 514337, 544333, 546113, 546175, 546256, 546262, 5462717, 5462821, 5462827
Abstract:
Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.