Yan He

20220271752, Aug 25, 2022

Dec 9, 2021

17/546438

- Santa Clara CA, US
Nikola Nedovic - San Jose CA, US
Yan He - Houston TX, US

NVIDIA Corp. - Santa Clara CA

H03K 19/003
H03K 19/0185

Bit generating cells are subjected to processes that accelerate aging-related characteristics before they are configured for use in the field (enrolled). Aging improves the reliability of the cells by shifting device characteristic in a direction that improves the cell behavior with respect not only to aging but also environment variations. Outputs of the cells are read, and the cells are reconfigured with a bias to output an opposite value, and then aged for enrollment.

20230049618, Feb 16, 2023

Aug 3, 2022

17/880379

- Charlotte NC, US
- Marvin NC, US
Kexin Huang - San Mateo CA, US
Yan He - Hayward CA, US

The University of North Carolina at Charlotte - Charlotte NC
OncoTAb, Inc. - Marvin

A61K 49/00
A61K 47/68
A61K 45/06

Provided are antibodies, and fragments and derivatives thereof, particularly humanized derivatives thereof, which bind to tumor antigens. Also provided are nucleic acid molecules encoding chimeric antigen receptors (CARs) that bind to tumor antigens, polypeptides and CARs encoded by the nucleic acid molecules, vectors and host cells that include the nucleic acid molecules, methods of making the same, and methods for using the same to generate a persisting population of genetically engineered T cells in a subject, expanding a population of genetically engineered T cells in a subject, modulating the amount of cytokine secreted by a T cell, reducing the amount of activation-induced calcium influx into a T cell, providing an anti-tumor immunity to a subject, treating a mammal having a MUC1-associated disease or disorder, stimulating a T cell-mediated immune response to a target cell population or tissue in a subject, and imaging a MUC1-associated tumor. Also provided are nanoparticle conjugates of the antibodies and fragments and derivatives thereof, particularly humanized derivatives thereof, compositions and delivery agents that include the same, host cells that produce the same; methods for producing the same; methods of using the same for detecting, targeting, and/or treating tumors and/or metastatic cells derived therefrom and/or tumor stem cells; and methods for predicting the recurrence of cancer in a subject.