Xiaohua He Phones & Addresses
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San Diego, CA
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Oceanside, CA
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Hockessin, DE
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Greenville, DE
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Brooklyn, NY
Publications
Us Patents
Cyclic Hydroxamic Acids As Metalloproteinase Inhibitors
View pageUS Patent:
6429213, Aug 6, 2002
Filed:
Jun 17, 1999
Appl. No.:
09/335086
Inventors:
Carl P. Decicco - Kennett Square PA, 19711
Xiaohua He - Hockessin DE, 19707
Xiaohua He - Hockessin DE, 19707
International Classification:
A61K 3147
US Classification:
514312, 514313, 514314, 514316, 514317, 514340, 514343, 514423, 514429, 546171, 546174, 546176, 546177, 546187, 546193, 546207, 546229, 5462764, 548530
Abstract:
The present application de gibes novel cyclic hydroxamic acids of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected from O, N, NR , and S(O) , and 0-1 carbonyl groups and the other variables are defined in the present specification, which are useful as metalloprotease inhibitors.
1,2,-Disubstituted Cyclic Inhibitors Of Matrix Metalloproteases And Tnf-Alpha
View pageUS Patent:
6642255, Nov 4, 2003
Filed:
Jan 9, 2002
Appl. No.:
10/043541
Inventors:
Carl Decicco - Kennett Square PA
Xiaohua He - Hockessin DE
Xiaohua He - Hockessin DE
Assignee:
Bristol-Myers Squibb Pharma Company - Princeton NJ
International Classification:
A61K 3147
US Classification:
514312, 546156, 546159
Abstract:
The present application describes novel 1,2-disubsituted cyclic derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-8 membered non-aromatic ring consisting of: carbon atoms, 0-1 carbonyl groups, 0-1 double bonds, and from 0-2 ring heteroatoms selected from O, N, NR , and S(O)p and the other variables are defined in the present specification, which are useful as metalloprotease and as TNF- inhibitors.
Cyclic Hydroxamic Acid As Metalloproteinase Inhibitors
View pageUS Patent:
6858626, Feb 22, 2005
Filed:
Jun 20, 2002
Appl. No.:
10/177235
Inventors:
Carl P. Decicco - Kennett Square PA, US
Xiaohua He - Hockessin DE, US
Xiaohua He - Hockessin DE, US
Assignee:
Bristol-Myers Squibb Pharma Company - Princeton NJ
International Classification:
A61K031/47
A61K031/16
C07C233/00
C07D211/72
C07D215/36
A61K031/16
C07C233/00
C07D211/72
C07D215/36
US Classification:
514312, 514330, 514346, 514613, 546153, 546225, 546298, 564163
Abstract:
The present application describes novel cyclic hydroxamic acids of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected from O, N, NR, and S(O), and 0-1 carbonyl groups and the other variables are defined in the present specification, which are useful as metalloprotease inhibitors.
Substituted 1,3-Dihydro-Imidazol-2-One And 1,3-Dihydro-Imidazol-2-Thione Derivatives As Inhibitors Of Matrix Metalloproteinases And/Or Tnf-Α Converting Enzyme (Tace)
View pageUS Patent:
7211671, May 1, 2007
Filed:
Sep 21, 2004
Appl. No.:
10/946418
Inventors:
James Sheppeck - Newtown PA, US
John L. Gilmore - Yardley PA, US
Xiaohua He - Hockessin DE, US
John L. Gilmore - Yardley PA, US
Xiaohua He - Hockessin DE, US
Assignee:
Bristol Myers Squibb Company - Princeton NJ
International Classification:
C07D 401/12
US Classification:
546152, 5483164, 5483251
Abstract:
The present invention describes novel 1,3-dihydro-imidazol-2-one or 1,3-dihydro-imidazol-2-thione compounds of formula (I):.
Macrocyclic Compounds As Metalloprotease Inhibitors
View pageUS Patent:
62813528, Aug 28, 2001
Filed:
May 14, 1997
Appl. No.:
8/856223
Inventors:
Carl P. Decicco - Newark DE
Robert J. Cherney - Newark DE
Elizabeth Arner - West Grove PA
William F. DeGrado - Moylan PA
Jingwu Duan - Newark DE
Xiaohua He - Hockessin DE
Irina Cipora Jacobson - Boothwyn PA
Ronald L. Magolda - Wallington PA
David Nelson - Newark DE
Robert J. Cherney - Newark DE
Elizabeth Arner - West Grove PA
William F. DeGrado - Moylan PA
Jingwu Duan - Newark DE
Xiaohua He - Hockessin DE
Irina Cipora Jacobson - Boothwyn PA
Ronald L. Magolda - Wallington PA
David Nelson - Newark DE
Assignee:
DuPont Pharmaceuticals Company - Wilmington DE
International Classification:
A61K 3133
C07D22504
C07D22500
C07D22504
C07D22500
US Classification:
540451
Abstract:
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tissue degradation and inhibitors of the release of tumor necrosis factor. The present invention also relates to pharmaceutical compositions comprising such compounds and to methods of using these compounds for the treatment of inflammatory diseases.
Sensitized Onium Salts
View pageUS Patent:
53470400, Sep 13, 1994
Filed:
Dec 9, 1992
Appl. No.:
7/988435
Inventors:
Arnost Reiser - Brooklyn NY
Xiaohua He - Brooklyn NY
Xiaohua He - Brooklyn NY
Assignee:
E. I. Du Pont de Nemours and Company - Wilmington DE
International Classification:
C07C 69017
C07C30100
C07C30102
C07F 940
C07C30100
C07C30102
C07F 940
US Classification:
560139
Abstract:
Onium salt capable of generating acid upon exposure to actinic radiation having the following structure: (R. sub. 1). sub. a (R. sub. 2). sub. b (R. sub. 3). sub. c Q. sup. + --A--M. sup. + X. sup. - --B--X'. sup. - where: Q is S; R. sub. 1, R. sub. 2 and R. sub. 3 are independently substituted or unsubstituted aromatic, aliphatic, or aralkyl groups having 7-18 carbon atoms; M. sup. + is a cationic organic radical; A is a divalent radical selected from the group of hindered alkylene groups, substituted or unsubstituted aromatic or aralkyl groups; B is a divalent aromatic sensitizer which absorbs radiation having a wavelength longer than 300 nm and is capable of transferring an electron to Q, x. sup. - and X'. sup. - are anionic groups; and wherein A provides a spatial separation between Q and M, and B provides a spatial separation between X and X', such that the spatial separation provided by A between Q and M is substantially the same as the spatial separation provided by B between X and X'.