Shiming Li from Edison, NJ, age 61

Resumes

Scientist At Rutgers University

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Position:

scientist at Rutgers University

Location:

Greater New York City Area

Industry:

Biotechnology

Work:

Rutgers University since 2010
scientist
WellGen, Inc. 2007 - 2010
Senior Scientist
Roche Pharmaceuticals 1999 - 2007
Senior Scientist
Johnson & Johnson 1996 - 1999
Associate Scientist

Education:

Rutgers, The State University of New Jersey-New Brunswick 2001 - 2005
Ph.D, Food Scientist Beijing University of Chemical Technology 1987 - 1992

Shiming Li

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Shiming Li New Brunswick, NJ

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Work:

Rutgers University

2010 to 2000
Visiting Research Professor
WellGen, Inc
North Brunswick, NJ
2008 to 2010
Senior Scientist
Roche Inc
Nutley, NJ
1999 to 2008
Senior Scientist, Associate Principle Scientist
Johnson & Johnson Pharmaceutical Research and Development, LLC
Raritan, NJ
1996 to 1999
Research Associate
Beijing University of Chemical Technology

1987 to 1992
Associate Professor

Education:

Rutgers University
New Brunswick, NJ
2002 to 2005
Ph.D. in Chemistry in Food Science
Texas A&M University
College Station, TX
M.Sc. in chemistry
Nankai University
China, ME
B.Sc. in Chemistry

Skills:

HPLC, LC/MS/MS, NMR (1D,2D), SFC, FT-IR, TLC, UV-vis, GC, flash chromatography, recrystalization, solid phase extraction, multi-step organic synthesis, UNIX, ChemDraw, ISIS database and ISIS Draw, SciFinder, Beilstein commander, software programming languages.

Student At New York University - Leonard N. Stern School Of Business

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Location:

Greater New York City Area

Industry:

Financial Services

Education:

New York University - Leonard N. Stern School of Business 2005 - 2009

Publications

Us Patents

Pyridopyrimidine Protein Tyrosine Phosphatase Inhibitors

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US Patent:

20070021445, Jan 25, 2007

Filed:

Jul 18, 2006

Appl. No.:

11/488863

Inventors:

Steven Berthel - Mendham Township NJ, US
Adrian Cheung - Glen Rock NJ, US
Kyungjin Kim - Livingston NJ, US
Shiming Li - Edison NJ, US
Kshitij Thakkar - Clifton NJ, US
Weiya Yun - Warren NJ, US

International Classification:

A61K 31/519
C07D 487/04

US Classification:

514264110, 544279000

Abstract:

The present invention comprises pyridopyrimidinediamine compounds of the general formula I: The compounds of the present invention are potent inhibitors of PTP1B. Accordingly, the invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.

Diacylglycerol Acyltransferase Inhibitors

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US Patent:

20070123504, May 31, 2007

Filed:

Nov 17, 2006

Appl. No.:

11/601429

Inventors:

David Bolin - Montclair NJ, US
Adrian Cheung - Glen Rock NJ, US
Fariborz Firooznia - Florham Park NJ, US
Matthew Hamilton - Hackettstown NJ, US
Shiming Li - Edison NJ, US
Lee McDermott - Parlin NJ, US
Yimin Qian - Wayne NJ, US
Weiya Yun - Warren NJ, US

International Classification:

A61K 31/541
A61K 31/5377
A61K 31/506
A61K 31/497
A61K 31/427
C07D 417/02
C07D 413/02

US Classification:

514210020, 544060000, 544124000, 544128000, 544405000, 544331000, 548190000, 540200000, 514227500, 514235500, 514235200, 514255050, 514256000, 514365000

Abstract:

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.

Hydroxylated Polymethoxyflavone Compositions

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US Patent:

20070275106, Nov 29, 2007

Filed:

Mar 14, 2007

Appl. No.:

11/724558

Inventors:

Chi-Tang Ho - East Brunswick NJ, US
Shiming Li - Glastonbury CT, US
Min-Hsiung Pan - Kaohsiung City, TW
Chih-Yu Lo - Somerset NJ, US
Slavik Dushenkov - Fort Lee NJ, US

International Classification:

A61K 31/352
A61K 36/00
A61K 36/752
A61P 35/00
C07D 311/30

US Classification:

424736000, 424725000, 514456000, 549403000

Abstract:

Provided herein are compositions enriched in polyhydroxylated polymethoxyflavones useful as dietary supplements, food additives, pharmaceutical compositions, nutraceutical compositions and cosmetic compositions.

Pyridopyrimidine Protein Tyrosine Phosphatase Inhibitors

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US Patent:

20090062276, Mar 5, 2009

Filed:

Oct 28, 2008

Appl. No.:

12/259737

Inventors:

Steven Joseph Berthel - Mendham Township NJ, US
Adrian Wai-Hing Cheung - Glen Rock NJ, US
Kyungjin Kim - Livingston NJ, US
Shiming Li - Edison NJ, US
Kshitij Chhabilbhai Thakkar - Clifton NJ, US
Weiya Yun - Warren NJ, US

International Classification:

A61K 31/519
C07D 471/04
A61P 3/10
A61K 31/5377

US Classification:

5142342, 544279, 544117, 51426411, 51425216

Abstract:

The present invention comprises pyridopyrimidinediamine compounds of the general formula I:The compounds of the present invention are potent inhibitors of PTP1B. Accordingly, the invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.

Diacylglycerol Acyltransferase Inhibitors

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US Patent:

20090076275, Mar 19, 2009

Filed:

Sep 10, 2008

Appl. No.:

12/207674

Inventors:

David Robert Bolin - Montclair NJ, US
Jianping Cai - West Caldwell NJ, US
Adrian Wai-Hing Cheung - Glen Rock NJ, US
Matthew Michael Hamilton - Hackettstown NJ, US
Shiming Li - Glastonbury CT, US
Lee Apostle McDermott - Parlin NJ, US
Weiya Yun - Warren NJ, US

International Classification:

C07D 413/12
C07D 417/12
C07D 471/04

US Classification:

546119, 548236, 548200, 5462704, 546199

Abstract:

Provided herein are compounds of the formula (I):as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.

Process Of Making Theaflavins Enriched Tea Extract

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US Patent:

20090092690, Apr 9, 2009

Filed:

Jul 24, 2008

Appl. No.:

12/220620

Inventors:

Hsiu Wei Yang - Erie PA, US
Shiming Li - Edison NJ, US
Bu-xiang Sun - Guilin, CN
Ling-zhi Tang - Guilin, CN
Bo-feng Wu - Guilin, CN
Zhi-hui Wang - Guilin, CN
Zhen-peng Chen - Guilin, CN

International Classification:

A61K 36/82
A23F 3/34
A23L 1/29
A23F 3/16
A61P 39/06
C09K 15/08
A61K 31/352

US Classification:

424729, 426655, 426648, 426429, 426546, 514456

Abstract:

This invention provides various products and processes such as a process of making a theaflavins enriched extract of tea having a low content of high molecular weight thearubigins which comprises extracting theaflavins from tea using ethanol to produce an extract having a high theaflavins content and a low content of high molecular weight thearubigins.

Diacylglycerol Acyltransferase Inhibitors

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US Patent:

20100168419, Jul 1, 2010

Filed:

Mar 11, 2010

Appl. No.:

12/722065

Inventors:

David Robert Bolin - Montclair NJ, US
Adrian Wai-Hing Cheung - Glen Rock NJ, US
Fariborz Firooznia - Florham Park NJ, US
Matthew Michael Hamilton - Hackettstown NJ, US
Shiming Li - Edison NJ, US
Lee Apostle McDermott - Parlin NJ, US
Yimin Qian - Wayne NJ, US
Weiya Yun - Warren NJ, US

International Classification:

C07D 417/14
C07D 413/14
C07D 413/12
C07D 239/48
C07D 417/12
C07D 401/12

US Classification:

544 582, 544131, 5462714, 544297, 544 586, 544133, 548192, 5462684, 5462754, 546194

Abstract:

Provided herein are compounds of the formula (I):as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.

Diacylglycerol Acyltransferase Inhibitors

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US Patent:

20100190979, Jul 29, 2010

Filed:

Jan 26, 2010

Appl. No.:

12/694069

Inventors:

International Classification:

C07D 413/14
C07D 401/12
C07D 413/10
C07D 401/14

US Classification:

544122, 544131, 544324, 5462714, 5462684

Abstract:

Provided herein are compounds of the formula (I):as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.