Resumes
Resumes
Mankil Jung Phones & Addresses
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81 Jeff St, Oxford, MS 38655 (662) 234-9305
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University, MS
Publications
Us Patents
Method Of Preparing (+)-Deoxoartemisinin And Selected Analogues Of (+)-Deoxoartemisinin
View pageUS Patent:
52255620, Jul 6, 1993
Filed:
Aug 10, 1990
Appl. No.:
7/565470
Inventors:
James D. McChesney - Etta MS
Mankil Jung - Oxford MS
Mankil Jung - Oxford MS
International Classification:
C07D49118
C07D32500
C07D32500
US Classification:
546270
Abstract:
This invention is a new method for preparing compounds useful as antimalarial agents having the formula; ##STR1## wherein R is hydrogen, a linear, branched or cyclo lower alkyl group having 1 to 8 carbon atoms; aminoalkyl; branched aminoalkyl; hydroxyalkyl: alkylcarboxylate or alkylbenzoate groups having 1 to 5 carbon atoms in the alkyl chains; aryl; alkoxy-substituted aryl; heteroaryl; and pyridinium groups. The method comprises treating artemisinic acid with a methylating agent followed by a stereoselective reduction of the methylated compound, subjecting the reduced compound to a Grignard addition followed by chiral photoxidation with subsequent treatment with a cyclization agent.
Deoxoartemisinin: New Compound And Composition For The Treatment Of Malaria
View pageUS Patent:
50233530, Jun 11, 1991
Filed:
Feb 22, 1990
Appl. No.:
7/482845
Inventors:
James D. McChesney - Etta MS
Mankil Jung - Oxford MS
Mankil Jung - Oxford MS
International Classification:
C07D32110
US Classification:
549348
Abstract:
This invention provides a new antimalarial compound, deoxoartemisinin, having the formula: ##STR1## Antimalarial compositions consisting essentially of the compound in admixture with a non-toxic, pharmaceutically-acceptable carrier. A method for treating malaria comprising administering a therapeutically effective concentration of the compound, preferably in admixture with a non-toxic, pharmaceutically-acceptable carrier. A method of preparing the deoxoartemisinin.
Deoxoartemisinin: New Compound And Composition For The Treatment Of Malaria
View pageUS Patent:
49201476, Apr 24, 1990
Filed:
Mar 28, 1989
Appl. No.:
7/329669
Inventors:
James D. McChesney - Etta MS
Mankil Jung - Oxford MS
Mankil Jung - Oxford MS
International Classification:
A61K 31335
C07D32102
C07D32102
US Classification:
514450
Abstract:
This invention provides a new antimalarial compound, deoxoartemisinin, having the formula: ##STR1## Antimalarial compositions consisting essentially of the compound in admixture with a non-toxic, pharmaceutically-acceptable carrier. A method for treating malaria comprising administering a therapeutically effective concentration of the compound, preferably in admixture with a non-toxic, pharamceutically-acceptable carrier. A method of preparing the doxoartemisinin.