Luhong He Phones & Addresses
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Indianapolis, IN
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Carlsbad, CA
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Albany, CA
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Boston, MA
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Cambridge, MA
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Carmel, IN
Publications
Us Patents
Anti-Hepcidin Antibodies And Uses Thereof
View pageUS Patent:
20090136495, May 28, 2009
Filed:
Oct 29, 2008
Appl. No.:
12/260125
Inventors:
Dennis Patrick Gately - San Diego CA, US
Donmienne Doen Mun Leung - San Diego CA, US
Barbara Anne Swanson - Encinitas CA, US
Ying Tang - San Diego CA, US
YuPing Anthony Cai - Carmel IN, US
LuHong He - Carmel IN, US
Peng Luan - Fishers IN, US
Derrick Ryan Witcher - Fishers IN, US
Donmienne Doen Mun Leung - San Diego CA, US
Barbara Anne Swanson - Encinitas CA, US
Ying Tang - San Diego CA, US
YuPing Anthony Cai - Carmel IN, US
LuHong He - Carmel IN, US
Peng Luan - Fishers IN, US
Derrick Ryan Witcher - Fishers IN, US
International Classification:
A61K 39/395
C07K 16/18
C12N 15/11
C12P 21/04
G01N 33/53
C12N 15/00
C12N 5/06
C07K 16/18
C12N 15/11
C12P 21/04
G01N 33/53
C12N 15/00
C12N 5/06
US Classification:
4241331, 5303873, 536 2353, 4353201, 435358, 435 696, 435 72
Abstract:
Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.