Linheng H Li

6703198, Mar 9, 2004

May 5, 2000

09/566047

Linheng Li - Seattle WA
Leroy Hood - Seattle WA
Ian D. Krantz - Philadelphia PA
Nancy B. Spinner - Bala Cynwyd PA

The University of Washington - Seattle WA
The Childrens Hospital of Philadelphia - Philadelphia PA

C12Q 168

435 6, 435 71, 530350, 530300, 536 231, 536 235

The present invention provides an isolated polypeptide exhibiting substantially the same amino acid sequence as JAGGED, or an active fragment thereof, provided that the polypeptide does not have the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6. The invention further provides an isolated nucleic acid molecule containing a nucleotide sequence encoding substantially the same amino acid sequence as JAGGED, or an active fragment thereof, provided that the nucleotide sequence does not encode the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6. Also provided herein is a method of inhibiting differentiation of hematopoietic progenitor cells by contacting the progenitor cells with an isolated JAGGED polypeptide, or active fragment thereof. The invention additionally provides a method of diagnosing Alagille Syndrome in an individual. The method consists of detecting an Alagille Syndrome disease-associated mutation linked to a JAGGED locus.

8106166, Jan 31, 2012

Mar 17, 2008

12/077290

Xi He - Leawood KS, US
Tong Yin - Prairie Village KS, US
Qiang Tian - Seattle WA, US
Weiguo Tao - West Lafayette IN, US
Leroy Hood - Seattle WA, US
Linheng Li - Leawood KS, US

Stowers Institute for Medical Research - Kansas City MO

C07K 16/26
C07K 16/00

53038824, 5303881, 5303879, 5303871, 435810

The present invention relates to a purified molecules, including antibodies, that bind specifically to murine β-catenin phosphorylated at amino acid position Serineand to orthologs thereof, such as mammalian orthologs, including human orthologs. Methods of making and using such purified molecules are also provided. Kits containing such purified molecules are further provided.

8263403, Sep 11, 2012

Apr 23, 2008

12/451038

John M. Perry - Olathe KS, US
Linheng Li - Kansas City MO, US
Justin C. Grindley - Kansas City MO, US

Stowers Institute for Medical Research - Kansas City MO

C12N 5/00
C12N 5/02
C12N 5/071
C12N 5/07
C12N 5/10

435377, 435375, 435372, 435355, 435325

The present invention relates to methods for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.

8476071, Jul 2, 2013

Aug 9, 2012

13/570534

John M. Perry - Olathe KS, US
Linheng Li - Kansas City MO, US
Justin C. Grindley - Kansas City MO, US

Stowers Institute for Medical Research - Kansas City MO

C12N 5/00
C12N 5/02
C12N 5/071
C12N 5/07
C12N 5/10

435405, 435377, 435374, 435372, 435355, 435325

The present invention relates to methods for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.

20040143863, Jul 22, 2004

Aug 14, 2003

10/641319

Linheng Li - Leawood KS, US
Jiwang Zhang - Overland Park KS, US

A01K067/027
C12N015/63

800/018000, 435/320100

The present invention relates to an isolated population of osteoblastic cells, which are characterized by cell surface markers N-cad and CD45, with such osteoblastic cells used in vitro to promote and support growth of HSCs. Additionally, the present invention relates to vectors, which include a Bmpr1a nucleic acid sequence, recombination sites, and a plasmid, wherein the vectors can be used to promote an increase in the HSC population in vivo.

20040162679, Aug 19, 2004

May 5, 2003

10/430201

Linheng Li - Leawood KS, US

G01N033/48

702/020000

The present invention relates to methods of associating nucleic acid sequences of unknown function with particular sub-populations, and methods of associating cells of unknown function with particular sub-populations. The method includes collecting hybridization data, developing a gene expression map, and comparing a nucleic acid sequence of unknown function to the gene expression map to determine in what sub-population the gene is expressed. The present invention also relates to kits, arrays, maps, isolated sequences, and clustered sequences.

20050271638, Dec 8, 2005

Jun 3, 2004

10/860501

Linheng Li - Leawood KS, US
Xi He - Leawood KS, US

A61K048/00
C12N005/08
C12N015/86

424093210, 435456000, 435366000, 514044000

The present invention relates to mutant BMP intestinal stem cells (ISCs), with these mutant ISCs possessing an inactive Bmpr1a receptor in which BMP binding is substantially inhibited. The present invention relates to vectors which comprise mutant Bmpr1a nucleic acid sequences, whereby the vectors can be used to promote an increase in the number of ISCs in vivo or in vitro.

20060073117, Apr 6, 2006

Oct 1, 2004

10/956882

Linheng Li - Leawood KS, US

A61K 39/395
A61K 35/14
C12N 5/08
C12N 5/06
C07H 21/04

424093100, 424145100, 435372000, 435326000, 530388250, 536023530

The present invention relates to mutant hair follicle stem cells possessing an inactive Bmpr1a receptor, wherein such mutant hair follicle stem cells proliferate and undergo self-renewal. Additionally, the present invention relates to compositions and methods for induction of hair follicle stem cell proliferation in vivo and in vitro. The present invention also relates to mutant Bmpr1a organisms and tumor cells.