Inventors:
John Wityak - West Grove PA, 19390
Aleksandra Ewa Tobin - Lincoln University PA, 19352
International Classification:
A61K 3147
US Classification:
514312, 514 63, 514 80, 514 81, 514183, 51421704, 51421707, 514218, 514274, 514275, 514300, 514303, 540542, 540553, 540554, 540575, 540597, 540599, 544229, 544243, 544318, 544331, 544332, 546 23, 546118, 546122, 546123, 546156, 546 14
Abstract:
This invention relates to novel fused heterocycles which are useful as antagonists of the and related integrin receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion, the treatment of angiogenic disorders, inflammation, bone degradation, cancer metastasis, diabetic retinopathy, thrombosis, restenosis, macular degeneration, and other conditions mediated by cell adhesion and/or cell migration and/or angiogenesis.