US Patent:
20190083638, Mar 21, 2019
Inventors:
- Durham NC, US
Jayanta Bhattacharyya - Durham NC, US
Robert A. Mook - Chapel Hill NC, US
Jiangbo Wang - Durham NC, US
Ivan Spasojevic - Durham NC, US
Richard Premont - Durham NC, US
Xinghai Li - Durham NC, US
Ashutosh Chilkoti - Durham NC, US
International Classification:
A61K 47/64
A61K 31/167
A61P 35/00
A61P 19/02
A61P 3/08
A61K 47/69
Abstract:
Disclosed herein are conjugates of a therapeutic compound and polypeptides, such as a conjugate of niclosamide and an elastin-like polypeptide. These conjugates may form nanoparticles through self-assembly, which improve the solubility, bioavailability, and pharmacokinetic profiles of the therapeutic compound. Also disclosed are methods for treating cancer, parasite infection, bacterial infection, viral infection, metabolic diseases, Type II diabetes, NASH, NAFLD, artery constriction, endometriosis, neuropathic pain, rheumatoid arthritis, sclerodermatous graft-versus-host disease, and systemic sclerosis.