Inventors:
Agustin Escobar - Aquadilla PR
Dietmar Wagenknecht - Zion IL
Ahmad W. Malick - Edison NJ
Assignee:
E. I. Du Pont de Nemours and Company - Wilmington DE
International Classification:
A61K 3124
Abstract:
A pharmaceutical composition is disclosed, which contains a short-acting. beta. -blocking compound of the formula ##STR1## wherein R. sub. 1 may be an alkyl, cycloalkyl, alkenyl, alkynyl, alkyl carboxymethyl, aryl carboxymethyl, aryl or aralkyl, A may be an alkylene or alkenylene, X may be independently amino, hydrogen, halogen, hydroxy, alkoxy, aryloxy, aralkyl, cyano, amido or trifluoromethyl, n is an integer from 1 to about 4, R may be an alkyl, propargyl, dimethylpropargyl or hydroxyalkyl; or a pharmaceutically acceptable salt thereof in a hydroalcoholic solution further containing a physiologically acceptable buffering agent, ethanol and a physiologically acceptable liquid polyhydric compound. A method for treatment or prophylaxis of cardiac disorders using the composition of the present invention is also disclosed.