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Zibo Li

from Chapel Hill, NC
Age ~47
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Also known as:
Li Zibo
Phone and address:
211 Lake Manor Rd, Chapel Hill, NC 27516
Related to:
Li YifeiJunran Li, 50Yinling L LiEnling Li, 64Wei Liu, 56Li Bing, 57Xiuqun Li, 54Le BingBangxian LiYinbo LiSteven T Li, 46Yan LiuChan M Chang, 72Qiaoxia Li, 47Liang W Chang, 72Yunqing Li, 54Liyun Chang, 67
Connected to:
Ai Q Li, 64Ai H Li, 81Aida Li, 67Aijun Li, 65Aiwen Q Li, 56Aiyan Li, 61Alan Li, 80Alice Li, 46Alida Li, 59Alisha Li, 31

Zibo Li Phones & Addresses

  • 211 Lake Manor Rd, Chapel Hill, NC 27516
  • San Gabriel, CA
  • Charlottesville, VA
  • Logan, UT
  • Los Angeles, CA
  • Mountain View, CA
  • Arcadia, CA
  • Menlo Park, CA
  • 1800 Jefferson Park Ave, Charlottesvle, VA 22903 (434) 244-5085

Work

Position: Food Preparation and Serving Related Occupations

Education

Degree: High school graduate or higher

Publications

Us Patents

Radiolabeled Bbn-Rgd Heterodimers For Cancer Targeting

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US Patent:
20100015058, Jan 21, 2010
Filed:
Jun 25, 2009
Appl. No.:
12/491905
Inventors:
ZIBO LI - LOGAN UT, US
XIAOYUAN CHEN - UNION CITY CA, US
Assignee:
STANFORD UNIVERSITY - PALO ALTO CA
International Classification:
A61K 49/04
C07K 5/00
C07K 5/12
C07K 7/06
C07K 7/08
G01N 33/53
A61K 49/00
A61P 35/00
US Classification:
424 944, 530317, 530330, 530327, 530328, 530329, 435 721, 424 91
Abstract:
The present disclosure encompasses heterodimeric compositions for delivering radiolabeled and other ligands to a cell or tissue, and particularly to compositions and methods of use thereof for targeting and imaging cells and tissues expressing both an integrin and gastrin-releasing peptide receptor, in particular prostate cancer cells. The disclosure, therefore, firstly encompasses compositions that can comprise a heterodimeric probe comprising a first peptide domain comprising a moiety capable of selectively binding to an integrin; a second peptide domain comprising a moiety capable of selectively binding to a gastrin-releasing peptide receptor; a linker connecting the first peptide domain and the second peptide domain; and a prosthetic group. The first peptide domain comprises at least one tripeptide comprising the amino acid sequence of arginine-glycine-aspartate, and the second domain can be the peptide bombesin(7-14). The prosthetic group can be the fluoride isotope F so that the heterodimeric probe may be detected by positron emission tomography or by single photon emission computed tomography, or a metal radionuclide. The radionuclide may be attached to the probe via a chelating tether.

Cage-Like Bifunctional Chelators, Copper-64 Radiopharmaceuticals And Pet Imaging Using The Same

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US Patent:
20100196271, Aug 5, 2010
Filed:
Jan 27, 2010
Appl. No.:
12/695125
Inventors:
Peter S. Conti - Pasadena CA, US
Hancheng Cai - Alhambra CA, US
Zibo Li - Logan UT, US
Assignee:
UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA
International Classification:
A61K 51/08
C07D 487/08
C07K 5/09
C07K 7/08
C07K 14/00
C07K 5/113
C07K 2/00
C07K 16/00
A61P 35/04
A61P 35/00
US Classification:
424 169, 540472, 530331, 530327, 530324, 530330, 530300, 5303911
Abstract:
Disclosed is a class of versatile Sarcophagine based bifunctional chelators (BFCs) containing a hexa-aza cage for labeling with metals having either imaging, therapeutic or contrast applications radiolabeling and one or more linkers (A) and (B). The compounds have the general formula

Synthesis Of 2'-Deoxy-2'-[18F]Fluoro-5-Methyl-1-B-D-Arabinofuranosyluracil (18F-Fmau)

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US Patent:
20120053337, Mar 1, 2012
Filed:
Jul 15, 2011
Appl. No.:
13/183924
Inventors:
Zibo Li - Logan UT, US
Hancheng Cai - Troy MI, US
Peter S. Conti - Pasadena CA, US
Assignee:
UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA
International Classification:
C07H 19/09
US Classification:
536 2854
Abstract:
The present invention relates to methods of synthesizing F-FMAU. In particular, F-FMAU is synthesized using one-pot reaction conditions in the presence of Friedel-Crafts catalysts. The one-pot reaction conditions are incorporated into a fully automated cGMP-compliant radiosynthesis module, which results in a reduction in synthesis time and simplifies reaction conditions. The one-pot reaction conditions are also suitable for the production of 5-substitued thymidine or cytidine analogues. The products from the one-pot reaction (e.g. the labeled thymidine or cytidine analogues) can be used as probes for imaging tumor proliferative activity. More specifically, these [F]-labeled thymidine or cytidine analogues can be used as a PET tracer for certain medical conditions, including, but not limited to, cancer disease, autoimmunity inflammation, and bone marrow transplant.

Boron-Based Dual Imaging Probes, Compositions And Methods For Rapid Aqueous F-18 Labeling, And Imaging Methods Using Same

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US Patent:
20130189185, Jul 25, 2013
Filed:
Jul 13, 2012
Appl. No.:
13/549309
Inventors:
Zibo LI - San Gabriel CA, US
Francois P. GABBAI - College Station TX, US
Peter S. CONTI - Pasadena CA, US
Todd W. HUDNALL - College Station TX, US
Tzu-Pin LIN - College Station TX, US
Shuanglong LIU - Alhambra CA, US
Assignee:
UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA
International Classification:
A61K 51/04
C07F 5/02
US Classification:
424 165, 548405, 424 96, 530331, 530317
Abstract:
A composition useful as a PET and/or fluorescence imaging probe a compound a compound of Formula I, including salts, hydrates and solvates thereof:

Tetrazine-Trans-Cyclooctene Ligation For The Rapid Construction Of Radionuclide Labeled Probes

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US Patent:
20130266512, Oct 10, 2013
Filed:
Jul 21, 2011
Appl. No.:
13/811568
Inventors:
Joseph M. Fox - Landenberg PA, US
Matthew Hassink - Wilmington DE, US
Melissa Blackman - Waltman MA, US
Zibo Li - Logan UT, US
Peter S. Conti - Pasadena CA, US
Ramajeyam Selvaraj - Newark DE, US
Assignee:
University of Southern California - Los Angeles CA
University of Delaware - Newark DE
International Classification:
A61K 51/04
US Classification:
424 189, 544179, 568667, 558272, 548546, 540460, 544235, 530399, 548549
Abstract:
A Diels-Alder adduct of a trans-cyclooctene with a tetrazine is provided, wherein the adduct bears a substituent labeled with a radionuclide. A method of producing a PET or other image of an organ in an animal or human includes forming the Diels-Alder adduct in the animal or human. Trans-cyclooctenes and tetrazines suitable for preparing the adducts are provided.

Imaging Compounds, Methods Of Making Imaging Compounds, Methods Of Imaging, Therapeutic Compounds, Methods Of Making Therapeutic Compounds, And Methods Of Therapy

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US Patent:
20080267882, Oct 30, 2008
Filed:
Apr 28, 2008
Appl. No.:
12/150473
Inventors:
Xiaoyuan Chen - Union city CA, US
Zibo Li - Logan UT, US
Assignee:
Stanford University - Palo Alto CA
International Classification:
A61K 49/04
C07K 5/09
C07K 7/06
C07K 14/00
C07K 5/12
G01N 33/483
A61K 49/00
US Classification:
424 94, 530331, 530329, 530328, 530325, 530317, 435 405, 424 91
Abstract:
Embodiments of the present disclosure provide for RGD compounds that include a multimeric RGD (arginine-glycine-aspartic acid (Arg-Gly-Asp)) peptide, methods of making the RGD compound, pharmaceutical compositions including RGD compound, methods of using the RGD compositions or the pharmaceutical compositions including RGD compositions, methods of diagnosing and/or targeting angiogenesis related disease and related biological events, kits for diagnosing and/or targeting angiogenesis related disease and related biological events, and the like. In addition, the present disclosure includes compositions used in and methods relating to non-invasive imaging (e.g., positron emission tomography (PET) imaging) of the RGD compounds in vivo.

Functionally Modified Maytansinoids And Compositions And Methods Of Use Thereof

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US Patent:
20230023368, Jan 26, 2023
Filed:
Nov 5, 2020
Appl. No.:
17/774843
Inventors:
- Athens GA, US
- Chapel Hill NC, US
Zibo Li - Chapel Hill NC, US
International Classification:
C07D 498/18
A61K 41/00
A61K 47/69
A61P 35/00
Abstract:
Radiosensitizer prodrugs and formulations and methods of use thereof are provided. Typically, the radiosensitizer prodrug is an analog of a radiosensitizer parent compound having one or more S-nitrosothiol moieties. Typically, the S—N bond of the S-nitrosothiol moiety can be cleaved by radiation during radiotherapy, releasing the parent compound and nitric oxide. One or preferably both the parent compound and the nitric oxide can contribute to death of tumor cells exposed to radiotherapy. Nanoparticle formulations for delivery of the prodrug, and methods of using them in combination with radiotherapy to treat tumors and cancer are also provided.

Probes For 18F Positron Emission Tomography Imaging

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US Patent:
20180340001, Nov 29, 2018
Filed:
Apr 19, 2018
Appl. No.:
15/957600
Inventors:
- College Station TX, US
- Chapel Hill NC, US
Kantapat Chansaenpak - College Station TX, US
Zibo Li - Chapel Hill NC, US
Mengzhe Wang - Chapel Hill NC, US
Hui Wang - Chapel Hill NC, US
International Classification:
C07F 9/6506
C07B 59/00
C07F 9/52
A61K 51/04
Abstract:
The present invention contemplates a method for synthesizing [F] fluoride complexes suitable for performing radio-labeling reactions to generate [F] fluorinated species for use as imaging agents. The present invention further contemplates kits for making [F] fluoride complexes suitable for performing radio-labeling reactions to generate [F] fluorinated species. The present invention further contemplates a method of using [F] fluoride prosthetic group for targeted tissue and disease imaging.
Control profile
Zibo Li from Chapel Hill, NC, age ~47 Get Report