Inventors:
Penglie Zhang - Foster City CA, US
Andrew M. K. Pennell - San Francisco CA, US
John J. Kim Wright - Redwood City CA, US
Wei Chen - Fremont CA, US
Manmohan R. Leleti - Sunnyvale CA, US
Yandong Li - San Jose CA, US
Lianfa Li - Palo Alto CA, US
Yuan Xu - Fremont CA, US
Mark M. Gleason - Redwood City CA, US
Yibin Zeng - San Mateo CA, US
Kevin Lloyd Greenman - Burlingame CA, US
Assignee:
Chemocentryx, Inc. - Mountain View CA
International Classification:
C07D 471/04
US Classification:
544362, 544236, 544262, 544350, 514249, 5142621, 514284, 51425304
Abstract:
Methods are provided for the synthesis of 1-[4-(substituted phenyl)-piperazin-1-yl ] -2- [3-(1H-imidazol-2-yl)-pyrazolo [3,4-b]pyridin-1-yl]-ethanone compounds via construction of the imidazole portion onto the corresponding aldehyde or nitrile compounds.