- Culver City CA, US Fabiola CECCHI - Potomac MD, US Yuan TIAN - Culver City CA, US Christina YAU - San Francisco CA, US Christopher SZETO - Culver City CA, US Todd HEMBROUGH - Gaithersburg MD, US Stephen Charles BENZ - Santa Cruz CA, US
International Classification:
G01N 33/68 A61K 31/704 A61P 35/00
Abstract:
Methods are provided for identifying whether a cancer patient, and especially a breast cancer patient, will be responsive to treatment. Specified TOPO2A, IDO1 and/or p16 fragment peptides are precisely detected and quantitated by SRM-mass spectrometry directly in cancer cells collected from tumor tissue that was obtained from a cancer patient and compared to reference levels in order to determine if the cancer patient will positively respond to treatment. Measurement of TOPO2A provides a direct indication of whether a patient will respond to anthracycline-containing therapy, and, in particular, neoadjuvant anthracycline-containing therapy. Quantitative levels of IDO1 and p16 are compared to reference levels in order to determine if a breast cancer patient will likely demonstrate a pathologically complete response (pCR) of cancer after cancer therapy treatment, irrespective of the chosen treatment.