Yan Yu Li

8304526, Nov 6, 2012

Jul 2, 2010

12/829651

Mien-Chie Hung - Houston TX, US
Yan Li - Houston TX, US
Yong Wen - Burlingame CA, US

The Board of Regents of the University of Texas System - Austin TX

C07H 21/04

536 235

The present invention regards mutant forms of Bik that comprise anti-cell proliferation and/or pro-apoptotic activities. In particular embodiments, the Bik polypeptides comprise a substitution at Thr33 and Ser35 and, in some embodiments, phosphorylation at these sites is inhibited. In more particular embodiments, these forms are useful for cancer therapy, particularly when administered in combination with liposomes. In embodiments wherein a mutant Bik polynucleotide is administered for cancer therapy, the polynucleotide may be regulated in a tissue-specific manner.

20050118154, Jun 2, 2005

Apr 2, 2004

10/816698

Mien-Chie Hung - Houston TX, US
Yan Li - Houston TX, US
Yong Wen - South San Francisco CA, US

A61K048/00
G01N033/53
G01N033/567
A61K038/53
C12N009/99

424094500, 435184000, 514044000

The present invention regards mutant forms of Bik that comprise anti-cell proliferation and/or pro-apoptotic activities. In particular embodiments, the Bik polypeptides comprise a substitution at Thr33 and Ser35 and, in some embodiments, phosphorylation at these sites is inhibited. In more particular embodiments, these forms are useful for cancer therapy, particularly when administered in combination with liposomes. In embodiments wherein a mutant Bik polynucleotide is administered for cancer therapy, the polynucleotide may be regulated in a tissue-specific manner.

20060192107, Aug 31, 2006

Oct 5, 2005

11/242842

Donald DeVoe - Bethesda MD, US
Yingxin Wang - Columbia MD, US
Cheng Lee - Ellicott City MD, US
Yan Li - Bethesda MD, US

B01D 59/44

250288000

Disclosed are an apparatus, system, and method for performing electrospray of biomolecules, particularly peptides, polypeptides, and proteins. The apparatus comprises at least (1) a microfluidic substrate for containing an electrospray microchannel for delivering analyte molecules to a side edge of the substrate, and (2) a porous membrane attached to the side edge for performing electrospray from the exposed membrane surface. In one preferred embodiment, the exposed membrane surface is positioned above a target surface for depositing analyte molecules onto the target surface by electrospray. In another preferred embodiment, a proteolytic enzyme is bound to the porous membrane for performing protein digestion during electrospray.

20090075885, Mar 19, 2009

Jul 28, 2008

12/180730

Mien-Chie Hung - Houston TX, US
Yan Li - Houston TX, US
Yong Wen - Burlingame CA, US

A61K 38/00
A61P 31/00

514 12

The present invention regards mutant forms of Bik that comprise anti-cell proliferation and/or pro-apoptotic activities. In particular embodiments, the Bik polypeptides comprise a substitution at Thr33 and Ser35 and, in some embodiments, phosphorylation at these sites is inhibited. In more particular embodiments, these forms are useful for cancer therapy, particularly when administered in combination with liposomes. In embodiments wherein a mutant Bik polynucleotide is administered for cancer therapy, the polynucleotide may be regulated in a tissue-specific manner.

20220292338, Sep 15, 2022

Mar 9, 2021

17/195755

- San Ramon CA, US
- Los Alamos NM, US
Yan Li - Houston TX, US
Margaretha Catharina Maria Rijken - Houston TX, US
Velimir Valentinov Vesselinov - Los Alamos NM, US

G06N 3/08
G06N 3/04

A computer implemented method for prediction of geomechanical performance including productivity index decline and completion integrity for a well or a hydrocarbon reservoir using a geomechanics informed machine intelligence (GIMI) algorithm. The method includes running a geomechanical reservoir simulator to generate training datasets for the hydrocarbon reservoir and incorporating physical models and identified variables into the GIMI algorithm. The method further includes training a neural network of the GIMI algorithm by using correlated training datasets that correlate to the physical models to produce a resulting prediction model and performing sensitivity analysis on the resulting prediction model. Additionally, the method includes identifying dominant variables for damage mechanisms through design of experiment statistics and performing history matching and blind test on the resulting prediction model. Lastly, the method includes updating the identified variables and models incorporated into the GIMI algorithm.

20210240773, Aug 5, 2021

Feb 2, 2021

17/165355

- Tysons Corner VA, US
Yan LI - Fairfax VA, US
Jinliang ZENG - Vienna VA, US
Feng DING - Fairfax VA, US

G06F 16/9032
G06K 9/00
G10L 15/22
H04W 4/80
G06K 7/14
G06K 7/10

According to certain aspects of the disclosure, a computer-implemented method may be used for analytics integration into electronic mediums. The method may include determining at least one insight discovery function from a plurality of insight discovery functions on a user device and enabling a software module based on the selection of the at least one insight discovery functions. Additionally, the method may include determining at least one key term based on the enabled software module, and determining at least one electronic data card associated with the at least one key term. Additionally, the method may include presenting the at least one data card to the user device based on a user interaction with the at least one insight discovery function on the user device.

20210142763, May 13, 2021

Oct 8, 2020

17/065837

- Tysons Corner VA, US
Liang CHEN - Fairfax VA, US
Jinliang ZENG - Vienna VA, US
Yan LI - Fairfax VA, US
Ting DONG - Annandale VA, US
Jose Manuel NOCEDAL DE LA GARZA - Leesburg VA, US
Nida IMTIAZ - Vienna VA, US

G09G 5/08
G06K 9/62
G09G 5/02

Methods, systems, and apparatus, including computer programs stored on computer-readable media, for displaying contextually relevant information, comprising receiving cursor data comprising a location of a cursor on an electronic display, and determining a screenshot of at least a portion of the electronic display. One or more proximate alphanumeric characters may be determined in at least a portion of the screenshot based on the location of the cursor, and at least one of the proximate alphanumeric characters may be matched with one or more terms from a predetermined list of terms. An information card may be caused to be displayed on the electronic display based on the location of the cursor, the information card corresponding to the one or more terms from the predetermined list of terms.

20210096277, Apr 1, 2021

Sep 25, 2020

17/033155

- San Ramon CA, US
Yan LI - Bellaire TX, US
Yunhui TAN - Katy TX, US
Ruiting WU - Sugar Land TX, US
Margaretha Catharina Maria RIJKEN - Houston TX, US
Amr Said EL-FAYOUMI - Houston TX, US
Pietro VALSECCHI - Duesseldorf, DE

CHEVRON U.S.A.INC. - San Ramon CA

G01V 99/00
E21B 47/06
G06F 30/20

Embodiments of evaluating production performance for a wellbore while accounting for subterranean reservoir geomechanics and wellbore completion are provided. One embodiment includes generating the wellbore model; defining geomechanical properties for the subterranean reservoir in the near wellbore region and the far field region, and completion variables for the wellbore completion; and simulating fluid flow in the near wellbore region, the far field region, and the wellbore completion to evaluate production performance for the wellbore over a period of time. A permeability of the subterranean reservoir and a contact area between the wellbore and the subterranean reservoir are updated during simulation over the period of time. The permeability and the contact area are updated as a function of a change in pressure and the geomechanical properties for the subterranean reservoir in the near wellbore region and the far field region, the completion variables for the wellbore completion, or any combination thereof.