US Patent:
20220339194, Oct 27, 2022
Inventors:
- Agoura Hills CA, US
Agnes Hamburger - Agoura Hills CA, US
Jee Young Mock - Agoura Hills CA, US
Julyun OH - Agoura Hills CA, US
Han Xu - Agoura Hills CA, US
Carl Alexander Kamb - Agoura Hills CA, US
International Classification:
A61K 35/17
C07K 14/725
C07K 16/28
C07K 16/30
Abstract:
The disclosure relates to immune cells comprising a dual receptor system responsive to loss of heterozygosity in a target cell, and methods of making and using same. The first receptor comprises activator receptor specific to a HER2 antigen, and the second receptor comprises an inhibitory receptor specific to an antigen lost in cancer but not wild type cells, that inhibits activation of the immune cells by the first receptor.