Wei Jun Li

6906067, Jun 14, 2005

Jun 26, 2001

09/891750

Kevin Joseph Moriarty - Norristown PA, US
Yvonne Shimshock - Hillsborough NJ, US
Gulzar Ahmed - Yardley PA, US
Junjun Wu - Malden MA, US
James Wen - Dayton NJ, US
Wei Li - Acton MA, US
Shawn David Erickson - Leonia NJ, US
Jeffrey John Letourneau - East Windsor NJ, US
Edward McDonald - Banstead, GB
Katerina Leftheris - Skillman NJ, US
Stephen T. Wrobleski - Whitehouse Station NJ, US
Zahid Hussain - Monmouth Junction NJ, US
Ian Henderson - Hopewell NJ, US
Axel Metzger - East Windsor NJ, US
John J. Baldwin - Gwynedd Valley PA, US
Alaric J. Dyckman - Lawrenceville NJ, US

Bristol-Myers Squibb Company - Princeton NJ
Pharmaceopeia, Inc. - Cranbury NJ

C07D251/40
C07D251/48
C07D251/52
A61K031/53
A61P035/00

514241, 544197, 544198, 544208, 544209, 544213, 544217, 544218

N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.

7479495, Jan 20, 2009

Jun 2, 2005

11/143430

Kevin Joseph Moriarty - Norristown PA, US
Yvonne Shimshock - Hillsborough NJ, US
Gulzar Ahmed - Yardley PA, US
Junjun Wu - Malden MA, US
James Wen - Dayton NJ, US
Wei Li - Acton MA, US
Shawn David Erickson - Leonia NJ, US
Jeffrey John Letourneau - East Windsor NJ, US
Edward McDonald - Banstead, GB
Katerina Leftheris - Skillman NJ, US
Stephen T. Wrobleski - Whitehouse Station NJ, US
Zahid Hussain - Monmouth Junction NJ, US
Ian Henderson - Hopewell NJ, US
Axel Metzger - East Windsor NJ, US
John J. Baldwin - Gwynedd Valley PA, US
Alaric J. Dyckman - Lawrenceville NJ, US

Pharmacopeia, Inc. - Cranbury NJ
Bristol-Myers Squibb Company - Princeton NJ

C07D 239/32
C07D 239/48
C07D 239/50
C07D 401/04
C07D 401/12
C07D 403/04
C07D 403/12
A61K 31/505
A61K 31/506
A61P 19/02
A61P 35/00

514269, 514272, 514273, 514275, 544317, 544320, 544321, 544323, 544326

N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I:Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.

20020065270, May 30, 2002

Dec 22, 2000

09/747195

Kevin Moriarty - Norristown PA, US
Yvonne Shimshock - Hillsborough NJ, US
Gulzar Ahmed - Yardley PA, US
Junjun Wu - Malden MA, US
James Wen - Dayton NJ, US
Wei Li - Acton MA, US
Shawn Erickson - Leonia NJ, US
Jeffrey Letourneau - East Windsor NJ, US
Edward McDonald - Surrey, GB
Katerina Leftheris - Skillman NJ, US
Stephen Wrobleski - Whitehouse Station NJ, US

A61K031/551
A61K031/53
A61K031/506
A61K031/4439
C07D251/42
C07D243/06

514/218000, 514/245000, 514/256000, 514/336000, 544/212000, 540/574000, 544/330000

N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF- expression utilizing compounds of the present invention are also disclosed.

20020094945, Jul 18, 2002

Nov 15, 2001

09/999290

Stephen Gross - Souderton PA, US
Wei Li - Mason OH, US
Norman Tuller - Simpsonville SC, US
Michael Wiggins - Lansdale PA, US

C11D003/37

510/475000

Reaction products of the reaction between reactants comprising A) at least one compound having the formula I below wherein R is a substituted or unsubstituted, saturated or unsaturated, organic group having from 4 to 36 carbon atoms; X is —O—, —S—, or —NR— where Ris hydrogen or a C-Calkyl group; Z is hydrogen, —NHRin place of a terminal —O— group wherein Rhas the meaning given above, or —SH in which the —SH group is present in place of a terminal —O— group; n is a number of from 0 to 100; m is a number of from 0 to 50; and p is a number of from 0 to 50; provided that the sum of n, m, and p is at least 1; wherein EO represents the residue of ethylene oxide, PO represents the residue of propylene oxide, and BO represents the residue of butylene oxide; and wherein the EO, PO, and BO groups when present can be in random and/or block distribution and can be in any order with respect to the X group; and B) a polyepoxide of formula II below wherein Ris hydrogen or a substituted or unsubstituted Cto Corganic group, and q is a number of from 2 to 10; and aqueous and nonaqueous compositions containing them.

20020103102, Aug 1, 2002

Oct 11, 2001

09/975357

Stephen Gross - Souderton PA, US
Wei Li - Mason OH, US
Jianhua Mao - West Chester OH, US
Norman Tuller - Simpsonville SC, US
Michael Wiggins - Lansdale PA, US

C11D001/00

510/499000

Reaction products of A) an amine of formula I wherein R is a substituted or unsubstituted, saturated or unsaturated, organic group having from 4 to 36 carbon atoms, Ris hydrogen or a C-Cstraight or branched chain alkyl group, optionally substituted with a hydroxyl group, X is —O—, —S—, or —NR— where Ris hydrogen or a C-Calkyl group, Z is ethylene, propylene or butylene, n is a number of from 0 to 100, m is a number of from 0 to 50: and p is a number of from 0 to 50, provided that the sum of n, m and p is at least one; and B) a multifunctional compound of formula II where Ris a straight or branched chain alkyl, alkenyl, or cycloaliphatic group having from 2 to 30 carbon atoms, or an unsubstituted or alkyl substituted aromatic group, the Y groups are carboxyl, carboxylic anhydride, halogen, carbonyl, acetyl halide, keto, aldehyde, or epoxy, and m is a number of from 2 to 10, and wherein the Y groups can be the same or different; and liquid compositions containing them.

20020111288, Aug 15, 2002

Oct 2, 2001

09/969281

Stephen Gross - Souderton PA, US
Wei Li - Mason OH, US
Norman Tuller - Simpsonville SC, US
Michael Wiggins - Lansdale PA, US
Norman Milstein - Cincinnati OH, US

C11D001/00

510/479000, 510/470000

The reaction product of (a) a polyol having from 2 to 30 carbon atoms and from 2 to 12 hydroxyl groups, or an alkyl polyglycoside, with (b) an alkoxide of the formula where R, R, Rand Rare each independently hydrogen or a C-Calkyl group. The above reaction products can then optionally be capped with one or more hydrophobic groups of the formula RX. The invention also relates to uses therefor as surfactants and defoaming agents in aqueous and nonaqueous liquid compositions.

20020137659, Sep 26, 2002

Dec 13, 2001

10/015479

Stephen Gross - Souderton PA, US
Wei Li - Mason OH, US
Norman Tuller - Simpsonville SC, US

C11D001/00

510/477000

Low foaming surfactants and/or defoaming agents, which are products of reactants comprising A) at least one compound having the formula I belowwherein R is a substituted or unsubstituted, saturated or unsaturated, organic group having from 4 to 36 carbon atoms; X is —O—, —S—, or —NR—where Ris hydrogen or a C-Calkyl group; n is a number of from 0 to 100; m is a number of from 0 to 50; and p is a number of from 0 to 50; provided that the sum of n, m, and p is at least 1; wherein EO represents the residue of ethylene oxide, PO represents the residue of propylene oxide, and BO represents the residue of butylene oxide; and wherein the EO, PO, and BO groups when present can be in random and/or block distribution and can be in any order with respect to the X group; and B) a polycarboxylic acid or derivatives thereof of formula IIwherein Ris a substituted or unsubstituted, saturated or unsaturated, organic group having from 3 to 36 carbon atoms, Y is independently halogen, or —ORwhere Ris hydrogen, a C-Calkyl group, or any two —COORgroups can form a carboxylic anhydride group; and x is a number of from 3 to 10.

20130051640, Feb 28, 2013

Jun 28, 2012

13/535607

Daphne Yu - Yardley PA, US
Wei Li - Princeton NJ, US
Feng Qiu - Plainsboro NJ, US

Siemens Corporation - Iselin NJ

G06K 9/00

382128

A method (100) of computing and displaying flow information of vascular blood flow patterns, especially in the form of quantitative data plots.