Kai Li

20040142495, Jul 22, 2004

Dec 16, 2003

10/737023

William Hartman - North Royalton OH, US
Kai Li - Diamond Bar CA, US
Daniel Holguin - Fullerton CA, US
Richard Sandt - Brunswick OH, US
Charles Herrmann - Cleveland Heights OH, US

G01N033/543

436/518000

An article for detecting the presence, or the absence, of an analyte. The analyte is indicative of a change in the status of a packaged material. The article generally includes a facestock film having first and second surfaces, an adhesive layer adjacent to the facestock film, and a detecting system adjacent to the facestock film. A measurable analyte can be in vapor and/or liquid form, and the detecting system indicates whether the analyte is present. That is, the detecting system responds to contact with the analyte by indicating that such contact has occurred, or that the analyte is present.

20160039857, Feb 11, 2016

Dec 4, 2013

14/649153

- Urbana IL, US
- La Jolla CA, US
Yonghui Zhang - Beijing, CN
William Sinko - La Jolla CA, US
Kai Li - Urbana IL, US
James Andrew McCammon - La Jolla CA, US
Eric Oldfield - Champaign IL, US

THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS - Urbana IL
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - La Jolla CA

C07H 15/26
C07D 233/24
A61K 31/4178
A61K 31/7056
C07H 15/203
A61K 31/506
C07D 243/04
A61K 31/551
A61K 31/7034
A61K 31/43
C07D 239/06

With the rise in resistance to antibiotics such as methicillin, there is a need for new drugs. The invention provides small molecules that inhibit cellular drug targets such as UPPS and FPPS by interacting with binding pockets, thereby preventing enzyme function. Compounds described herein are also active against (MIC900.25 μg/mL), can potently synergize with methicillin (fractional inhibitory concentration index=0.25), and are protective in a mouse infection model. The invention therefore provides numerous compounds for anti-bacterial treatments and for restoring sensitivity to drugs such as methicillin, using combination therapies.