Jun S Xu

6504008, Jan 7, 2003

Feb 1, 1999

09/241888

Jun Xu - Ossining NY
Joshua Trueheart - South Nyack NY

Cadus Technologies, Inc. - New York NY

C07K 1400

530350, 530371

The present invention makes available a rapid, reproducible, robust assay system for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular protein, e. g. , a receptor or ion channel. The subject assay enables rapid screening of large numbers of compounds to identify those which act as an agonist or antagonist to the bioactivity of the cellular protein. In particular, the assay of the invention makes use of a cell that harbors a protein that is responsive to a cellular signal transduction pathway. The protein is operatively linked to a polypeptide which causes a detectable signal to be generated upon stimulation of the pathway, e. g. , when a compound interacts with and modulates the activity of a cellular receptor or ion channel of the cell. Thus, the cell provides a signal generation means comprising a novel fusion protein the expression of which is independent of stimulation/activation of the signal transduction pathway, but the activity of which is responsive to the signal transduction pathway.

7022513, Apr 4, 2006

Jul 18, 2002

10/200013

Jun Xu - Ossining NY, US
Joshua Trueheart - South Nyack NY, US

Cadus Technologies, Inc. - New York NY

C12N 1/16

4352551, 435243, 4352541, 43525411, 4352542, 43525421, 4352552

The present invention makes available a rapid, reproducible, robust assay system for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular protein, e. g. , a receptor or ion channel. The subject assay enables rapid screening of large numbers of compounds to identify those which act as an agonist or antagonist to the bioactivity of the cellular protein. In particular, the assay of the invention makes use of a cell that harbors a protein that is responsive to a cellular signal transduction pathway. The protein is operatively linked to a polypeptide which causes a detectable signal to be generated upon stimulation of the pathway, e. g. , when a compound interacts with and modulates the activity of a cellular receptor or ion channel of the cell. Thus, the cell provides a signal generation means comprising a novel fusion protein the expression of which is independent of stimulation/activation of the signal transduction pathway, but the activity of which is responsive to the signal transduction pathway.

20040202605, Oct 14, 2004

Apr 13, 2004

10/823230

Jun Xu - Piscataway NJ, US
Gaurav Jain - Piscataway NJ, US

C01G049/02
H01M004/52

423/632000, 429/221000

Iron oxyhydroxide materials possessing short-range-order structure and nanostructured morphology capable of intercalating lithium ions and being used as electrodes for electrochemical energy devices including rechargeable lithium batteries, and synthesis method thereof.

20040213731, Oct 28, 2004

Dec 19, 2003

10/742272

Jun Xu - Piscataway NJ, US
Gaurav Jain - Piscataway NJ, US

C01G049/02

423/633000

An iron oxide based host material capable of intercalating lithium ions includes nanostructured phases composed of at least substantially amorphous nanometer sized particles, and is applicable for use in the cathode electrode of a lithium rechargeable battery.

20050135993, Jun 23, 2005

Dec 23, 2003

10/744395

Jun Xu - Piscataway NJ, US
Jingsi Yang - Piscataway NJ, US
Gaurav Jain - Piscataway NJ, US

C01G045/02
H01M004/50

423605000, 429231100, 429224000

The present invention is directed to a process for making an amorphous nanostructured cation-doped manganese oxide material useful as an ion intercalation host for rechargeable batteries, including the steps of preparing a solution containing cation permanganate combined optionally with a cation donor compound, mixing the solution with a reducing agent to yield a hydrogel comprising a manganese oxide compound, cryogenically freezing the hydrogel, drying the frozen gel to yield a cryogel amorphous nanostructured cation-doped manganese oxide, and heat treating the dried cryogel.