Jie Li

20120234569, Sep 20, 2012

Nov 14, 2011

13/295719

Chris Lawton - Costa Mesa CA, US
Jie Li - Rancho Santa Margarita CA, US
De L. San - La Verne CA, US
Nathan Lee - Escondido CA, US

B25B 23/14

173181

A system, and a method of using a system, for controlled tool operation. The method includes providing a tool used in a force application such as a such torque application. The tool communicates with a controller which can communicate with the tool, and to a display in communication with the tool and the controller. The controller can be programmed with operational information about a tool operation. Information related to the operational information is displayed to a user during use. Service information including at least information about an amount of force applied during use is recorded and stored in the controller. Also disclosed is a computerized system for controlled tool operation which sends operational instructions to the tool before use and retrieves service information from the tool after use.

20180369159, Dec 27, 2018

Dec 14, 2016

16/063221

- Oakland CA, US
Jie LI - Los Angeles CA, US
Yang LIU - Los Angeles CA, US
Jie REN - Los Angeles CA, US
Jing WEN - Culver City CA, US

A61K 9/51
A61K 38/38

The invention relates to protein nanocapsules that exhibit material properties that change in different in vivo environments. A zwitterion moiety on the surface of the nanocapsule can protect the protein from opsonization in a first environment, yet uncouples from the protein nanocapsule in a second environment (e.g. at a pH of less than 6.5). In embodiments of the invention, the uncoupled protein nanocarrier is then internalized by mammalian cells (e.g. tumor cells).

20160361425, Dec 15, 2016

Feb 23, 2015

15/120899

- Oakland CA, US
Juanjuan Du - Los Angeles CA, US
Jie Li - Los Angeles CA, US
Yang Liu - Los Angeles CA, US

A61K 47/48
A61K 38/44
A61K 38/51

Methods for modifying therapeutic agents such as therapeutic biomolecules, such as proteins for improved oral, rectal or transmucosal delivery, as well as compositions made using such methods and methods of administering such compositions to a subject, are disclosed. Specifically, the therapeutic agents are conjugated to hyperbranched polymers (HBPs), such as hyperbranched polyglycerol (HPG). When such conjugates are administered orally to a subject, the HBP protects the therapeutic agent from the acid environment of the stomach and protease attack in the gastro-intestinal tract, while facilitating the absorption of the therapeutic agent in the higher pH environment of the intestines. The methods and compositions are useful for the improved administration of a variety of therapeutic agents to a subject.