US Patent:
20090098050, Apr 16, 2009
Inventors:
Daniel Yarbrough - Los Angeles CA, US
Wenyuan Shi - Los Angeles CA, US
Elizabeth Hagerman - Beverly Hills CA, US
Sotirios Tetradis - Culver City CA, US
Fengxia Qi - Laguna Niguel CA, US
Jian He - Los Angeles CA, US
Bruce Rutherford - Seattle WA, US
Randal Eckert - Ellensburg WA, US
Ben Wu - San Marino CA, US
Assignee:
THE REGENTS OF THE UNVERSITY OF CALIFORNIA - Oakland CA
International Classification:
A61K 49/00
C07K 7/00
A61K 38/04
A61K 38/05
A61K 38/07
A61K 38/08
A61K 38/10
A61K 38/16
US Classification:
424 91, 530331, 530330, 530329, 530328, 530327, 530326, 530325, 530324, 514 18, 514 19, 514 17, 514 16, 514 15, 514 14, 514 13, 514 12
Abstract:
Disclosed herein are a class of compounds comprising peptides of the sequence (X-Y-Z), wherein X is an amino acid selected from aspartic acid, glutamic acid, asparagine, alanine and glutamine, and Y and Z are amino acids selected from alanine, serine, threonine, phosphoserine, phosphothreonine, and their derivatives. These compounds have the property of binding tightly and specifically to calcified surfaces, making them useful for a variety of applications including remineralization of tooth and bone surfaces, diagnosis of bone and tooth defects, treatment of bone and tooth defects, and analysis of the presence and location of calcified deposits both in vitro and in vivo and in industrial, synthetic, medical, dental, and research applications where identification, localization, or manipulation of calcification is desirable.