US Patent:
20210017171, Jan 21, 2021
Inventors:
- South San Francisco CA, US
Chengguo DONG - Staten Island NY, US
Timothy HOM - Sunnyvale CA, US
Lan JIANG - Foster City CA, US
Katerina LEFTHERIS - San Mateo CA, US
Hui LI - Santa Clara CA, US
Manuel MUNOZ - Vallejo CA, US
Maureen REILLY - Burlingame CA, US
Yajun ZHENG - Foster City CA, US
International Classification:
C07D 471/04
C07D 519/00
Abstract:
The invention relates to compounds of formula (A) and formula (I):or a salt thereof, wherein R, R, R, R, R, R, R, R, R, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are αvβ6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).