Inventors:
- Bethesda MD, US
- University Park PA, US
Cen Xie - Rockville MD, US
Andrew D. Patterson - State College PA, US
Fei Li - Rockville MD, US
James B. Mitchell - Damascus MD, US
Shantu Amin - Union City NJ, US
Dhimant Desai - Mechanicsburg PA, US
Assignee:
The United States of America, as represented by the Secretary, Dept. of Health and Human Services - Bethesda MD
The Penn State Research Foundation - University Park PA
International Classification:
C07J 41/00
C07J 31/00
Abstract:
Disclosed are inhibitors of the farnesoid X receptor, for example of formula (I), wherein R, R, R, X, Y, Z, m, and n are as defined herein, which are useful in treating or preventing obesity, type 2 diabetes/insulin resistance and non-alcoholic fatty liver disease in a mammal in need thereof. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the invention, a method of method of inhibiting a farnesoid X receptor in a mammal, and a method of treating or preventing obesity in a mammal.