Dan Li

8036735, Oct 11, 2011

Aug 8, 2007

11/835812

Shelley M. Cazares - Washington DC, US
Haresh G. Sachanandani - Shoreview MN, US
Benjamin Ettori - Pittsburgh PA, US
Dan Li - Shoreview MN, US
Yanting Dong - Shoreview MN, US

Cardiac Pacemakers, Inc. - St. Paul MN

A61B 5/044
A61B 5/0452

600523, 600510, 600522

A system evaluates the performance of an implantable medical device, such as by using a remote external server and a user interface and stored historical physiological data of a population of congestive heart failure (CHF) patients. A processor is coupled to a patient data storage device to apply multiple algorithm variations against the same implantable physiological data from the patient to produce corresponding resulting CHF indicators. The user interface includes a display that is configured to display to a user information allowing comparison between the resulting CHF indicators from the multiple algorithm variations. The display also includes a population data selector to permit the user to select physiological data from a population that includes a different set of one or more patients or physiological data collected over a period of time from the patient. This permits optimization of an algorithm parameter or selection of a best performing algorithm.

8271088, Sep 18, 2012

Jul 20, 2010

12/839913

Shelley M. Cazares - Washington DC, US
Dan Li - Shoreview MN, US
Jonathan Kwok - Holmdel NJ, US

Cardiac Pacemakers, Inc. - St. Paul MN

A61N 1/362

607 32

This document discusses, among other things, methods and systems for facilitating automated device programming at changeout. A method comprises receiving, from a first device, physiological data at a temporary storage device; and processing the received physiological data, wherein the processing includes determining if a first signal processing function was used by the first device and substantially offsetting the first signal processing function if the first signal processing function was used by the first device; and processing the resultant physiological data to be compatible with a second device. The method further comprising providing the processed resultant physiological data to the second device.

8521289, Aug 27, 2013

Sep 5, 2012

13/603934

Shelley M. Cazares - Washington DC, US
Dan Li - Shoreview MN, US
Jonathan Kwok - Holmdel NJ, US

Cardiac Pacemakers, Inc. - St. Paul MN

A61N 1/362

607 32

This document discusses, among other things, methods and systems for facilitating automated device programming at changeout. A method comprises receiving, from a first device, physiological data at a temporary storage device; and processing the received physiological data, wherein the processing includes determining if a first signal processing function was used by the first device and substantially offsetting the first signal processing function if the first signal processing function was used by the first device; and processing the resultant physiological data to be compatible with a second device. The method further comprising providing the processed resultant physiological data to the second device.

20220380471, Dec 1, 2022

Oct 21, 2020

17/770940

- Bethesda MD, US
Ruixue Wang - Bethesda MD, US
Brad St. Croix - Frederick MD, US
Dan Li - Rockville MD, US

The U.S.A., as represented by the Secretary, Department of Health and Human Services - Bethesda MD

C07K 16/28
A61P 35/00
G01N 33/574

Single-domain monoclonal antibodies that specifically bind B7H3 (also known as CD276) are described. The single-domain antibodies include camel VH and rabbit VH domain nanobodies selected from phage display libraries. Chimeric antigen receptors (CARs) and other antibody conjugates targeted to B7H3 are also described. The single-domain antibodies and conjugates thereof can be used for the diagnosis and treatment of B7H3 expressing solid tumors.

20210371542, Dec 2, 2021

Nov 7, 2018

16/762459

- Bethesda MD, US
Nan Li - Laurel MD, US
Dan Li - Bethesda MD, US

The U.S.A., as represented by the Secretary, Department of Health and Human Services - Bethesda MD

C07K 16/30
C07K 14/715
C07K 14/71
C07K 14/705
C07K 14/725
A61K 35/17
A61P 35/00

Nucleic acid constructs encoding a chimeric antigen receptor (CAR) and a truncated human epidermal growth factor receptor (huEGFRt) are described. The encoded CARs include a tumor antigen-specific monoclonal antibody, such as a glypican-3 (GPC3)-specific, a GPC2-specific or a mesothelin-specific monoclonal antibody, fused to a CD8α hinge region, a CD8α transmembrane region, a 4-1BB co-stimulatory domain and a CD3ζ signaling domain. Isolated host cells, such as isolated T cells that co-express the disclosed CARs and huEGFRt are also described. T cells transduced with the disclosed CAR constructs can be used for cancer immunotherapy.