US Patent:
20120316066, Dec 13, 2012
Inventors:
Robert Eugene HORMANN - Melrose Park PA, US
Bing Li - Shrewsbury MA, US
Assignee:
Intrexon Corporation - Blacksburg VA
International Classification:
A61K 31/166
C07D 317/68
C07D 319/18
C07D 333/38
C07D 213/56
C07D 307/68
C12N 5/00
C12N 15/87
C12P 21/00
A61K 31/357
A61K 31/381
A61K 31/341
A61K 31/44
A61P 35/00
A01N 37/18
A01N 43/26
A01N 43/32
A01N 43/10
A01N 43/08
A01N 43/40
A01P 13/00
A01P 21/00
C07C 241/02
US Classification:
504260, 564310, 549436, 549362, 549 72, 546316, 549487, 435375, 435465, 435468, 435 691, 514615, 514466, 514452, 514448, 514471, 514355, 504335, 504296, 504293, 504289, 504299
Abstract:
The present invention provides diacylhydrazine ligands and chiral diacylhydrazine ligands for use with ecdysone receptor-based inducible gene expression systems. Thus, the present invention is useful for applications such as gene therapy, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable. An advantage of the present invention is that it provides a means to regulate gene expression and to tailor expression levels to suit the user's requirements.