Inventors:
- Princeton NJ, US
Murugaiah Andappan Murugaiah Subbaiah - Hosur, IN
Carolyn Diane Dzierba - Middletown CT, US
Hua Gong - King of Prussia PA, US
Jason M. Guernon - Pipersville PA, US
Junqing Guo - Princeton NJ, US
Amy C. Hart - Ewing NJ, US
Guanglin Luo - Madison CT, US
John E. Macor - Washington Crossing PA, US
William J. Pitts - Newtown PA, US
Jianliang Shi - Furlong PA, US
Brian Lee Venables - Durham CT, US
Carolyn A. Weigelt - Langhorne PA, US
Yong-Jin Wu - Madison CT, US
Zhizhen Barbara Zheng - Cheshire CT, US
Jie Chen - Cambridge MA, US
International Classification:
C07D 487/04
Abstract:
The disclosure relates to compounds of formula I which are useful as kinase modulators including RIPK 1 modulation. The disclosure also provides methods of making and using the compounds for example in treatments related to necrosis or inflammation as well as other indications.