Inventors:
Zhiyong Qiu - Los Angeles CA, US
Adrian Ion Bot - Valencia CA, US
Assignee:
MannKind Corporation - Valencia CA
International Classification:
C07H 21/02
C12K 15/11
Abstract:
The present invention provides a method of treating cancer by providing to a subject in need thereof an immunogenic composition comprising a nucleic acid construct encoding a polypeptide comprising CTL epitopes PSMAand PRAME, or a cross-reactive analogue. In embodiments of the present invention there is provided methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response.