Zhida Huang

7569675, Aug 4, 2009

Sep 11, 2002

10/242092

Haiying Xia - Union City CA, US
Zhida Huang - Fremont CA, US

Spring Bioscience Corporation - Fremont CA

C07K 16/28
C12P 21/08
G01N 33/53
G01N 33/531
G01N 33/554
G01N 33/567
G01N 33/577
C12N 5/12
G01N 33/574

53038822, 435 723, 435 795, 435 4052, 435 7021, 435449, 435334, 435960, 436503, 436518, 436519, 436548, 436813

A lagomorph derived monoclonal antibody for recognizing the progesterone receptor (PR) (clone SP2) with immunohistochemistry and methods for creating such an antibody are disclosed. No need of target retrieval in immunohistochemistry is their prominent advantage compared to currently available PR antibody. Furthermore, the very low background when the lagomorph derived monoclonal antibody is used in immunohistochemistry is also impressive. The immunohistochemistry comparative study with about fifty clinical specimens showed that the new PR antibody (clone SP2) antibody had favorable results when compared to mouse monoclonal antibody PR (clone 1A6), the best one in the current market. The PR antibody may prove of great value in the assessment of PR status in human breast cancer. Humanized versions of the PR antibody may provide therapeutic benefits.

20040142400, Jul 22, 2004

Sep 11, 2002

10/242088

Haiying Xia - Union City CA, US
Zhida Huang - Fremont CA, US

G01N033/53

435/007920

High affinity monoclonal antibodies for recognizing estrogen receptor (clone SP1) with immunohistochemistry and methods for creating such an antibody are disclosed. The lagomorph derived ER antibody provides a significant advantage over the currently available mouse ER antibodies in that there is no need for target retrieval when performing immunohistochemistry. Furthermore, the very low background when the lagomorph derived ER antibody is used in immunohistochemistry is also impressive. The immunohistochemistry comparative study with about fifty clinical specimens showed that the new ER (clone SP1) antibody had favorable results when compared to mouse monoclonal ER antibodies (clone 1D5). The lagomorph derived ER antibody may prove of great value in the assessment of ER status in human breast cancer. Humanized versions of the ER antibody may also provide therapeutic benefits.