Inventors:
Zheqing Wang - East Haven CT, US
Lijan Shu - Dongyang, CN
Weifeng Guo - Dongyang, CN
HangChang Zhu - Dongyang, CN
Pingai Yang - Dongyang, CN
Xiaofeng Shen - Dongyang, CN
Chenming Jin - Dongyang, CN
International Classification:
C07D 498/06
C07D 403/10
Abstract:
A novel and practical process for selectively producing a pyridobenzoxazine carboxylic acid hemihydrate (e. g. , (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3-de] [1,4]benzoxazine-6-carboxylic acid hemihydrate) in high yield via crystallization from an organic solvent or a mixed organic solvent system containing a calculated amount of water released from sodium sulfate decahydrate under gradually heating.