Inventors:
Tapas De - Los Angeles CA, US
Neil P. Desai - Los Angeles CA, US
Andrew Yang - Rosemead CA, US
Zachary Yim - Los Angeles CA, US
Patrick Soon-Shiong - Los Angeles CA, US
Assignee:
Abraxis Bioscience, LLC - Los Angeles CA
International Classification:
A61K 31/7072
A61K 31/337
A61K 31/282
A61K 9/14
A61K 33/24
US Classification:
424489, 514449, 514 49, 514492, 424649
Abstract:
The present invention provides stable pharmaceutical compositions of poorly water soluble pharmaceutical agents and stabilizing agents which function to increase stability of the compositions. The use of stabilizing agents provide extended stability of nanoparticle suspensions and other formulations of poorly water soluble pharmaceutical agents such as docetaxel under certain conditions, for example upon dilution for administration.