Yousang Gwack

20090178146, Jul 9, 2009

Jan 5, 2007

12/160030

Anjana Rao - Cambridge MA, US
Stefan Feske - New York NY, US
Patrick Hogan - Cambridge MA, US
Yousang Gwack - Los Angeles CA, US

IMMUNE DISEASE INSTITUTE, INC. - Boston MA

A01K 67/027
G01N 33/53
C12Q 1/02
C12Q 1/68
C07K 16/18
C12N 5/06

800 3, 435 721, 435 29, 435 6, 5303879, 435325

Disclosed are methods of identifying an agent that modulates an NFAT regulator protein. One such method comprises contacting at least one test agent with a recombinant cell comprising at least one NFAT regulator protein or fragment or derivative thereof, assessing the effect of the test agent on an activity, interaction, expression, or binding to the NFAT regulator protein or fragment or derivative thereof, and identifying the test agent that has an effect on an activity, interaction, expression, or binding to the NFAT regulator protein or fragment or derivative thereof, whereby the identified test agent is characterized as an agent that modulates an NFAT regulator protein. Methods of identifying an agent that modulates intracellular calcium, methods to screen for an agent that modulates NFAT regulator function, methods to diagnose unexplained immunodeficiency in a subject, and methods for identifying an agent for treating or preventing a disease or disorder associated with a NFAT regulator protein or calcium signaling are also disclosed.

20110269174, Nov 3, 2011

Jun 15, 2011

13/161307

Anjana RAO - Cambridge MA, US
Stefan Feske - New York MA, US
Patrick Hogan - Cambridge MA, US
Yousang Gwack - Los Angeles CA, US

Immune Disease Institute, Inc. - Boston MA

C12Q 1/02
C12N 5/10

435 29, 435325, 435366, 435352, 435348

Disclosed are methods of identifying an agent that modulates an NFAT regulator protein. One such method comprises contacting at least one test agent with a recombinant cell comprising at least one NFAT regulator protein or fragment or derivative thereof, assessing the effect of the test agent on an activity, interaction, expression, or binding to the NFAT regulator protein or fragment or derivative thereof, and identifying the test agent that has an effect on an activity, interaction, expression, or binding to the NFAT regulator protein or fragment or derivative thereof, whereby the identified test agent is characterized as an agent that modulates an NFAT regulator protein. Methods of identifying an agent that modulates intracellular calcium, methods to screen for an agent that modulates NFAT regulator function, methods to diagnose unexplained immunodeficiency in a subject, and methods for identifying an agent for treating or preventing a disease or disorder associated with a NFAT regulator protein or calcium signaling are also disclosed.

20180194821, Jul 12, 2018

Feb 20, 2018

15/900698

- Boston MA, US
Stefan Feske - New York NY, US
Patrick Hogan - Cambridge MA, US
Yousang Gwack - Los Angeles CA, US

CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA

C07K 14/47
G01N 33/50
C07K 16/18
C12N 15/90
A61K 35/12
C12N 5/16
C07H 21/04
C12Q 1/00
C12N 15/63

Disclosed are methods of identifying an agent that modulates an NFAT regulator protein. One such method comprises contacting at least one test agent with a recombinant cell comprising at least one NFAT regulator protein or fragment or derivative thereof, assessing the effect of the test agent on an activity, interaction, expression, or binding to the NFAT regulator protein or fragment or derivative thereof, and identifying the test agent that has an effect on an activity, interaction, expression, or binding to the NFAT regulator protein or fragment or derivative thereof, whereby the identified test agent is characterized as an agent that modulates an NFAT regulator protein. Methods and tools for identifying an agent that modulates intracellular calcium, to screen for an agent that modulates NFAT regulator function, to diagnose unexplained immunodeficiency in a subject, and for identifying an agent for treating or preventing a disease or disorder associated with a NFAT regulator protein or calcium signaling are also disclosed.

20160052981, Feb 25, 2016

Aug 21, 2015

14/832922

- Boston MA, US
Stefan Feske - New York MA, US
Patrick Hogan - Cambridge MA, US
Yousang Gwack - Los Angeles CA, US

CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA

C07K 14/47

Disclosed are methods of identifying an agent that modulates an NFAT regulator protein. One such method comprises contacting at least one test agent with recombinant cell comprising at least one NFAT regulator protein or fragment or derivative thereof, assessing the effect of the test agent on an activity, interaction, expression, or binding to the NFAT regulator protein or fragment or derivative thereof, and identifying the test agent that has an effect on an activity, interaction, expression, or binding to the NFAT regulator protein or fragment or derivative thereof, whereby the identified test agent is characterized as an agent that modulates an NFAT regulator protein. Methods of identifying an agent that modulates intracellular calcium, methods to screen for an agent that modulates NFAT regulator function, methods to diagnose unexplained immunodeficiency in a subject, and methods for identifying an agent for treating or preventing a disease or disorder associated with a NFAT regulator protein or calcium signaling are also disclosed.