US Patent:
20220362358, Nov 17, 2022
Inventors:
- San Francisco CA, US
- Stanford CA, US
Yiyin E. Chen - Stanford CA, US
International Classification:
A61K 39/00
C12N 15/62
C12N 15/74
C12N 1/20
C12N 5/0783
A61P 37/06
Abstract:
Provided are modified microorganisms, such as live recombinant commensal bacteria, that express a heterologous antigen, and methods of using the modified microorganisms to induce an antigen-specific immune response to the heterologous antigen. The modified microorganism can be used to induce a regulatory T cell immune response to the heterologous antigen to treat an autoimmune disease in a subject in need thereof, or can be used to induce an effector T cell immune response to the heterologous antigen to treat a proliferative disease in a subject in need thereof.