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Xueni Guan

from San Diego, CA
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Connected to:
Agnes L Guan, 81Alex Y Guan, 40Anne Guan, 39Annie J Guan, 43Ben H Guan, 47Bin Guan, 54Carol Y Guan, 46Changhui Guan, 60Chen B Guan, 66Ching S Guan, 65

Xueni Guan Phones & Addresses

  • Solana Beach, CA
  • San Diego, CA

Work

Company: Centers for disease control and prevention Mar 2007 to Jun 2010 Position: Laboratory program coordinator

Education

Degree: Doctorates, Doctor of Philosophy School / High School: Iowa State University 1989 to 1994 Specialities: Biology, Philosophy

Skills

Genetics • Biotechnology • Genomics • Molecular Biology • Lifesciences • Bioinformatics • Pcr • Science • Glp • Research • Protein Purification • Cell Biology

Languages

Mandarin

Industries

Research

Resumes

Resumes

Xueni Guan Photo 1

Xueni Guan

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Location:
San Diego, CA
Industry:
Research
Work:
Centers For Disease Control and Prevention Mar 2007 - Jun 2010
Laboratory Program Coordinator
Syngenta Feb 2003 - Jul 2006
Staff Scientist
Education:
Iowa State University 1989 - 1994
Doctorates, Doctor of Philosophy, Biology, Philosophy Jilin University 1981 - 1986
Bachelors, Biochemistry
Skills:
Genetics
Biotechnology
Genomics
Molecular Biology
Lifesciences
Bioinformatics
Pcr
Science
Glp
Research
Protein Purification
Cell Biology
Languages:
Mandarin

Publications

Us Patents

Method For The Integration Of Foreign Dna Into Eukaryotic Genomes

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US Patent:
6541231, Apr 1, 2003
Filed:
Oct 12, 1999
Appl. No.:
09/415839
Inventors:
Christopher L. Baszczynski - Urbandale IA
Leszek Alexander Lyznik - Johnston IA
William J. Gordon-Kamm - Urbandale IA
Xueni Guan - San Diego CA
Aragula Gururaj Rao - Urbandale IA
Laura A. Tagliani - Ankeny IA
Assignee:
Pioneer Hi-Bred International, Inc. - Des Moines IA
International Classification:
C12N 900
US Classification:
435183, 435193, 435 691, 435 697, 435462, 435468, 800278
Abstract:
Compositions and methods for introducing a DNA of interest into a genomic target site are provided. In particular, the methods and compositions involve the use of a combination of target sites for two site specific recombinases and expression of a chimeric recombinase with dual target site specificity. Thus, the compositions comprise novel site-specific recombinases with specificities to multiple target sites, and nucleotide sequences and expression cassettes encoding these recombinases or target sites. The methods involve transforming a eukaryotic cell having target sites for the novel recombinase with a DNA of interest that is flanked by corresponding target sites. Expression of the recombinase results in integration of the DNA of interest into the genome of the cell. The compositions and methods of the invention have use in the construction of stably transformed eukaryotic cells, and in particular, plant cells. The methods result in the efficient targeted genomic integration of DNA by site-specific recombination.

Mobilization Of Viral Genomes From T-Dna Using Site-Specific Recombination Systems

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US Patent:
6664108, Dec 16, 2003
Filed:
Oct 1, 1999
Appl. No.:
09/411826
Inventors:
Christopher L. Baszczynski - Urbandale IA
Leszek Alexander Lyznik - Johnston IA
William J. Gordon-Kamm - Urbandale IA
Xueni Guan - San Diego CA
Assignee:
Pioneer Hi-Bred International, Inc. - Johnston IA
International Classification:
C12N 1582
US Classification:
435469, 435419, 4353201, 536 231, 800278, 800205
Abstract:
The invention relates to methods and compositions for site-specific recombinase-mediated mobilization of viral replicons and associated DNAs of interest from T-DNA. The methods of the invention comprise Agrobacterium-mediated transfer of T-DNA to a plant cell, wherein the T-DNA contains a viral replicon flanked by directly repeated target sites for a site-specific recombinase and optionally a DNA of interest linked to the viral replicon. The DNA of interest may also contain a non-identical target site for the recombinase. An expression cassette for the site-specific recombinase is present on the T-DNA or the plant genome, or is transiently introduced into the plant cell. Expression of the site-specific recombinase in the plant cell results in excision of the viral replicon and the associated DNA of interest. The viral replicon and DNA of interest are then replicated to high copy number in the host plant cell. The compositions of the invention comprise nucleic acids, such as T-DNAs containing a viral DNA flanked by directly repeated target sites for a site-specific recombinase.

Methods And Compositions To Modulate Expression In Plants

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US Patent:
7151201, Dec 19, 2006
Filed:
Jan 19, 2001
Appl. No.:
09/765555
Inventors:
Justin T. Stege - San Diego CA, US
Xueni Guan - San Diego CA, US
Bipin Dalmia - San Diego CA, US
Assignee:
The Scripps Research Institute - La jolla CA
Syngenta Participations AG - Basel
International Classification:
C12N 15/09
C12N 15/82
A01H 5/00
US Classification:
800278, 800298, 800295, 435468, 4353201
Abstract:
The invention relates to the field of plant and agricultural technology. More specifically, the invention relates to the use of zinc finger proteins and fusions of said proteins to regulate gene expression and metabolic pathways in plants.

Mobilization Of Viral Genomes From T-Dna Using Site-Specific Recombination Systems

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US Patent:
7179599, Feb 20, 2007
Filed:
May 23, 2003
Appl. No.:
10/444664
Inventors:
Christopher L. Baszczynski - Urbandale IA, US
Leszek Alexander Lyznik - Johnston IA, US
William J. Gordon-Kamm - Urbandale IA, US
Xueni Guan - San Diego CA, US
Assignee:
Pioneer Hi-Bred International, Inc. - Johnston IA
International Classification:
C12Q 1/68
C12N 1/12
C12N 1/20
C12N 15/00
C12N 15/09
US Classification:
435 6, 435325, 4353201, 4352523, 435410
Abstract:
The invention relates to methods and compositions for site-specific recombinase-mediated mobilization of viral replicons and associated DNAs of interest from T-DNA. The methods of the invention comprise -mediated transfer of T-DNA to a plant cell, wherein the T-DNA contains a viral replicon flanked by directly repeated target sites for a site-specific recombinase and optionally a DNA of interest linked to the viral replicon. The DNA of interest may also contain a non-identical target site for the recombinase. An expression cassette for the site-specific recombinase is present on the T-DNA or the plant genome, or is transiently introduced into the plant cell. Expression of the site-specific recombinase in the plant cell results in excision of the viral replicon and the associated DNA of interest. The viral replicon and DNA of interest are then replicated to high copy number in the host plant cell. The compositions of the invention comprise nucleic acids, such as T-DNAs containing a viral DNA flanked by directly repeated target sites for a site-specific recombinase.

Method For The Integration Of Foreign Dna Into Eukaryotic Genomes

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US Patent:
7223601, May 29, 2007
Filed:
Jan 29, 2003
Appl. No.:
10/353445
Inventors:
Christopher L. Baszczynski - Urbandale IA, US
Leszek Alexander Lyznik - Johnston IA, US
William J. Gordon-Kamm - Urbandale IA, US
Xueni Guan - San Diego CA, US
Aragula Gururaj Rao - Urbandale IA, US
Laura A. Tagliani - Zionsville IN, US
Assignee:
Pioneer Hi-Bred International, Inc. - Des Moines IA
International Classification:
C12N 15/87
US Classification:
435462, 435468, 800278
Abstract:
Compositions and methods for introducing a DNA of interest into a genomic target site are provided. In particular, the methods and compositions involve the use of a combination of target sites for two site specific recombinases and expression of a chimeric recombinase with dual target site specificity. Thus, the compositions comprise novel site-specific recombinases with specificities to multiple target sites, and nucleotide sequences and expression cassettes encoding these recombinases or target sites. The methods involve transforming a eukaryotic cell having target sites for the novel recombinase with a DNA of interest that is flanked by corresponding target sites. Expression of the recombinase results in integration of the DNA of interest into the genome of the cell. The compositions and methods of the invention have use in the construction of stably transformed eukaryotic cells, and in particular, plant cells. The methods result in the efficient targeted genomic integration of DNA by site-specific recombination.

Mobilization Of Viral Genomes From T-Dna Using Site-Specific Recombination Systems

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US Patent:
7364902, Apr 29, 2008
Filed:
Apr 7, 2006
Appl. No.:
11/400293
Inventors:
Christopher L. Baszczynski - Urbandale IA, US
Leszek Alexander Lyznik - Johnston IA, US
William J. Gordon-Kamm - Urbandale IA, US
Xueni Guan - San Diego CA, US
Assignee:
Pioneer Hi-Bred International, Inc, - Des Moines IA
International Classification:
C12N 15/82
C12N 5/04
C12N 5/10
A01H 1/00
C07H 21/00
C07H 21/02
US Classification:
435469, 435419, 4353201, 435455, 536 231, 800260, 800278
Abstract:
The invention relates to methods and compositions for site-specific recombinase-mediated mobilization of viral replicons and associated DNAs of interest from T-DNA. The methods of the invention comprise -mediated transfer of T-DNA to a plant cell, wherein the T-DNA contains a viral replicon flanked by directly repeated target sites for a site-specific recombinase and optionally a DNA of interest linked to the viral replicon. The DNA of interest may also contain a non-identical target site for the recombinase. An expression cassette for the site-specific recombinase is present on the T-DNA or the plant genome, or is transiently introduced into the plant cell. Expression of the site-specific recombinase in the plant cell results in excision of the viral replicon and the associated DNA of interest. The viral replicon and DNA of interest are then replicated to high copy number in the host plant cell. The compositions of the invention comprise nucleic acids, such as T-DNAs containing a viral DNA flanked by directly repeated target sites for a site-specific recombinase.

Synthetic Zinc Finger Protein Encoding Sequences And Methods Of Producing The Same

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US Patent:
7378510, May 27, 2008
Filed:
Dec 14, 2006
Appl. No.:
11/639706
Inventors:
Justin T. Stege - San Diego CA, US
Xueni Guan - San Diego CA, US
Bipin Dalmia - San Diego CA, US
Assignee:
The Scripps Research Institute - La Jolla CA
Syngenta Participations AG - Basel
International Classification:
C12N 15/09
C12N 15/82
A01H 5/00
US Classification:
536 231, 4353201, 435468, 435 691, 4352551
Abstract:
The invention relates to nucleic acids encoding synthetic zinc finger proteins for gene regulation in plants. The invention also relates to methods of producing synthetic zinc finger protein in host cells.

Expression System For Synthetic Zinc Finger Proteins And Methods Of Using The Same

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US Patent:
7781645, Aug 24, 2010
Filed:
May 27, 2008
Appl. No.:
12/127763
Inventors:
Justin T. Stege - San Diego CA, US
Xueni Guan - San Diego CA, US
Bipin Dalmia - San Diego CA, US
Assignee:
Syngenta Participations AG - Basel
The Scripps Research Institute - La Jolla CA
International Classification:
C12N 15/09
C12N 15/82
A01H 5/00
US Classification:
800278, 800295, 800298, 435468, 4353201
Abstract:
The invention relates to the field of plant and agricultural technology. More specifically, the invention relates to the use of zinc finger proteins and fusions of said proteins to regulate gene expression and metabolic pathways in plants.
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Xueni Guan from San Diego, CA Get Report