Inventors:
Tassie Collins - San Mateo CA, US
Hossen Mahmud - San Antonio TX, US
Jonathan Houze - San Mateo CA, US
Alan Xi Huang - San Mateo CA, US
Julio C. Medina - San Carlos CA, US
Xuemei Wang - San Mateo CA, US
Feng Xu - Palo Alto CA, US
Qingge Xu - Burlingame CA, US
Liusheng Zhu - Burlingame CA, US
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
C07D 417/12
C07D 419/12
C07D 401/00
A61K 31/425
US Classification:
514365, 548181, 544137, 546209
Abstract:
Compounds, compositions and methods are provided that are useful in the treatment of chemokine receptor-mediated conditions and diseases. In particular, the invention provides compounds which modulate CCR4 function or a CCR4-mediated response. The subject compounds and compositions are useful for the treatment or prevention of inflammatory conditions and diseases.