US Patent:
20110065762, Mar 17, 2011
Inventors:
Jizhou Wang - Eagleville PA, US
Xiaodong Fan - Center Valley PA, US
Lidia Cristian - Princeton Junction NJ, US
International Classification:
A61K 31/423
C07C 211/19
C07D 233/60
C07C 255/47
C07C 251/20
C07C 251/18
C07C 23/38
C07D 263/52
A61K 31/13
A61K 31/4164
A61K 31/155
A61K 31/04
A61P 31/16
US Classification:
514375, 564456, 564459, 5483411, 558429, 564270, 564225, 570187, 548223, 514659, 514662, 514399, 514638, 514631, 514740
Abstract:
The present invention relates, in part, to methods of treatment, prevention, and inhibition of viral disorders. In one aspect, the present invention relates to inhibition of the M2 proton channel of influenza viruses (e.g. influenza A virus) and other similar viroporins (e.g., VP24 of Ebola and Marburg viruses; and NS3 protein of Bluetongue). The present invention further relates, inter alia, to compounds which have been shown to possess antiviral activity, in particular, inhibiting the M2 proton channel of influenza viruses.