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William S Shestowsky

from San Diego, CA
Age ~62

William Shestowsky Phones & Addresses

  • 7652 Marker Rd, San Diego, CA 92130 (858) 538-1004
  • 1126 Pacifica Pl, Encinitas, CA 92024 (760) 635-9457
  • 1126 Pacifica Pl, Encinitas, CA 92024 (619) 894-1580

Work

Position: Executive, Administrative, and Managerial Occupations

Education

Degree: High school graduate or higher

Emails

w***y@aol.com

Publications

Us Patents

Treatment Of Psoriasis Using Anti-B7.1 (Cd80) Antibodies

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US Patent:
6709654, Mar 23, 2004
Filed:
Aug 26, 1999
Appl. No.:
09/383916
Inventors:
Darrell R. Anderson - Escondido CA, 92029
Peter Brams - San Diego CA, 92116
Nabil Hanna - Rancho Santa Fe CA, 92067
William S. Shestowsky - San Diego CA, 92109
Cheryl Heard - Encinitas CA, 92024
International Classification:
A61K 39395
US Classification:
4241531, 4241301, 4241411, 4241431, 4241441, 4241541, 4241731, 5303871, 5303881, 5303882, 53038822, 5303887, 53038873, 53038875
Abstract:
The present invention relates to the identification of macaque antibodies to human B7. 1 and B7. 2 by screening of phage display libraries or monkey heterohybridomas obtained using B lymphocytes from B7. 1 and/or B7. 2 immunized monkeys. More specifically, the invention provides four monkey monoclonal antibodies 7B6, 16C10, 7C10 and 20C9 which inhibit the B7:CD28 pathway and thereby function as effective immunosuppressants. The invention further provides the complete DNA and amino acid sequences of the light and heavy chain of three primatized antibodies derived from those monkey monoclonal antibodies which bind B7. 1 and possibly B7. 2, primatized 7C10, primatized 7B6 and primatized 16C10. These primatized and monkey antibodies may be used as specific immunosuppressants, e. g. , for the treatment of autoimmune diseases and to prevent organ transplant rejection.

Methods For Treating B Cell Lymphoma Using Cd80-Specific Antibodies

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US Patent:
6893638, May 17, 2005
Filed:
Jan 12, 2001
Appl. No.:
09/758173
Inventors:
Darrell R. Anderson - Escondido CA, US
Peter Brams - San Diego CA, US
Nabil Hanna - Rancho Santa Fe CA, US
William S. Shestowsky - San Diego CA, US
Cheryl Heard - Encinitas CA, US
International Classification:
A61K039/395
C07K016/28
US Classification:
4241531, 4241301, 4241331, 4241381, 4241411, 4241431, 4241441, 4241551, 4241731, 4241741, 5303871, 5303873, 5303877, 5303881, 5303882, 53038822, 5303887, 53038873, 5303888
Abstract:
The present invention relates to methods for treating B cell lymphoma using CD80-specific antibodies.

Anti-Cd80 Antibodies

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US Patent:
7323170, Jan 29, 2008
Filed:
Nov 15, 2004
Appl. No.:
10/986780
Inventors:
Darrell R. Anderson - Escondido CA, US
Peter Brams - San Diego CA, US
Nabil Hanna - Rancho Santa Fe CA, US
William S. Shestowsky - San Diego CA, US
Cheryl Heard - Encinitas CA, US
Assignee:
Biogen Idec Inc. - Cambridge MA
International Classification:
A61K 39/395
C07K 16/28
US Classification:
4241531, 4241301, 4241331, 4241381, 4241411, 4241431, 4241441, 4241551, 4241731, 5303871, 5303873, 5303881, 5303882, 53038822, 5303887
Abstract:
The present invention relates to the identification of macaque antibodies to human B7. 1 and B7. 2 by screening of phage display libraries or monkey heterohybridomas obtained using B lymphocytes from B7. 1 and/or B7. 2 immunized monkeys. More specifically, the invention provides four monkey monoclonal antibodies 7B6, 16C10, 7C10 and 20C9 which inhibit the B7:CD28 pathway and thereby function as effective immunosuppressants. The invention further provides the complete DNA and amino acid sequences of the light and heavy chain of three PRIMATIZED antibodies derived from those monkey monoclonal antibodies which bind B7. 1 and possibly B7. 2, PRIMATIZED 7C10, PRIMATIZED 7B6 and PRIMATIZED 16C10. These PRIMATIZED and monkey antibodies may be used as specific immunosuppressants, e. g. , for the treatment of autoimmune diseases and to prevent organ transplant rejection.

Monoclonal Antibodies For Measuring Okadaic Acid

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US Patent:
52645568, Nov 23, 1993
Filed:
Mar 27, 1992
Appl. No.:
7/858991
Inventors:
Hanna Sikorska - Quebec, CA
William S. Shestowsky - San Diego CA
Assignee:
Rougier Inc. - Montreal
International Classification:
C07K 1500
US Classification:
5303872
Abstract:
The present invention relates to an anti-idiotypic monoclonal antibody raised against a mouse monoclonal antibody or fragments thereof specific to at least one diarrhetic shellfish poisoning toxin selected from the group consisting of okadaic acid and derivatives thereof. The anti-idiotypic antibody is characterized by reacting only with antibodies to okadaic acid and derivatives thereof but not with antibodies directed against any other compounds. The anti-idiotypic antibody is further characterized by being an internal image of okadaic acid and derivatives thereof. A hybridoma producing an anti-idiotypic antibody in accordance with the present invention has been deposited at the ATCC under accession number HB 10768. Competitive solid-phase assays for determining the amount of okadaic acid and derivatives thereof in marine samples are also provided in accordance with the present invention. The present invention also relates to a kit for determining the amount of okadaic acid and derivatives thereof in marine samples.

Human B7.1-Specific Primatized Antibodies And Transfectomas Expressing Said Antibodies

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US Patent:
61138983, Sep 5, 2000
Filed:
Jun 7, 1995
Appl. No.:
8/487550
Inventors:
Darrell R. Anderson - Escondido CA
Peter Brams - San Diego CA
Nabil Hanna - Rancho Santa Fe CA
William S. Shestowsky - San Diego CA
Cheryl Heard - Encinitas CA
Assignee:
IDEC Pharmaceuticals Corporation - San Diego CA
International Classification:
A61K 39395
C12N 510
C07K 1628
C07H 2102
US Classification:
4241331
Abstract:
The present invention relates to the identification of macaque antibodies to human B7. 1 and B7. 2 by screening of phage display libraries or monkey heterohybridomas obtained using B lymphocytes from B7. 1 and/or B7. 2 immunized monkeys. More specifically, the invention provides four monkey monoclonal antibodies 7B6, 16C10, 7C10 and 20C9 which inhibit the B7:CD28 pathway and thereby function as effective immunosuppressants. The invention further provides the complete DNA and amino acid sequences of the light and heavy chain of three primatized antibodies derived from those monkey monoclonal antibodies which bind B7. 1 and possibly B7. 2, primatized 7C10, primatized 7B6 and primatized 16C10. These primatized and monkey antibodies may be used as specific immunosuppressants, e. g. , for the treatment of autoimmune diseases and to prevent organ transplant rejection.
William S Shestowsky from San Diego, CA, age ~62 Get Report