Weina Sun Phones & Addresses
-
Greenvale, NY
-
Flushing, NY
-
Williamsburg, VA
-
Woodhaven, NY
Publications
Us Patents
Mosaic Influenza Virus Hemagglutinin Polypeptides And Uses Thereof
View pageUS Patent:
20210260179, Aug 26, 2021
Filed:
Jun 20, 2019
Appl. No.:
17/252638
Inventors:
- New York NY, US
Peter PALESE - New York NY, US
Florian KRAMMER - New York NY, US
Felix BRÖCKER - Berlin, DE
Weina SUN - New York NY, US
Peter PALESE - New York NY, US
Florian KRAMMER - New York NY, US
Felix BRÖCKER - Berlin, DE
Weina SUN - New York NY, US
Assignee:
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI - New York NY
International Classification:
A61K 39/145
C07K 14/005
C12N 7/00
G01N 33/50
A61P 31/16
A61P 37/04
C07K 14/005
C12N 7/00
G01N 33/50
A61P 31/16
A61P 37/04
Abstract:
In one aspect, provided herein is a mosaic influenza virus hemagglutinin (HA) polypeptide comprising an influenza A virus HA ectodomain of an influenza A virus strain HA, wherein the HA ectodomain comprises an HA stem domain of the influenza A virus strain HA and an HA globular head domain of the influenza A virus strain HA, wherein the HA globular head domain of the influenza A virus strain HA has been engineered to comprise one or more amino acid substitutions in one, two, three, four or all of the antigenic sites. In another aspect, provided herein are immunogenic compositions comprising such a mosaic influenza virus HA polypeptide or an influenza A virus comprising such a mosaic influenza virus HA polypeptide. In yet another aspect, provided herein are methods for immunizing a subject against an influenza A vims in a subject comprising administering such an immunogenic composition to the subject.