Weidan Peng

20060228404, Oct 12, 2006

Oct 21, 2005

11/256452

Daniel Anderson - Framingham MA, US
Robert Langer - Newton MA, US
Robert Padera - Milton MA, US
Weidan Peng - Haverford PA, US
Janet Sawicki - Newton Square PA, US

A61K 48/00
A61K 31/785
A61K 9/127
C12N 15/88

424450000, 424078270, 514044000, 977907000, 435458000

The present invention provides compositions and methods for treatment of conditions and diseases associated with excessive or inappropriate noncancerous tissue growth. In certain embodiments of the invention the compositions and methods are used for treatment of benign prostatic hyperplasia. In certain embodiments of the invention the composition comprises a tissue-selective delivery vehicle. In certain embodiments of the invention the compositions comprise an expression vector that encodes a cytotoxic polypeptide, wherein expression of the cytotoxic polypeptide is under control of a prostate-specific regulatory element. In certain embodiments of the invention the compositions comprise an expression vector in which expression of a recombinase is under control of a prostate-specific regulatory element, and a recombination event mediated by the recombinase is required for expression of the cytotoxic polypeptide.

20050215507, Sep 29, 2005

Mar 4, 2005

11/074323

Daniel Anderson - Framingham MA, US
Robert Langer - Newton MA, US
Janet Sawicki - Newton Square PA, US
Weidan Peng - Haverford PA, US

Massachusetts Institute of Technology - Cambridge MA
Lankenau Institute for Medical Research - Wynnewood PA

A61K048/00
C07H021/04
C12N015/85

514044000, 435455000

Aspects of the invention relate to nucleic acids molecules that are useful for specifically destroying selected cells, tissues, or organs. Aspects of the invention are useful for treating diseases (e.g., cancer) that affect specific cells, tissues, or organs.