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Veysel Kayser

from Melrose, MA
Age ~52
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Connected to:
Annette M Kayser, 68Austin D Kayser, 32Constance S Kayser, 70Cristofre D Kayser, 62Denise R Kayser, 62Eddie Kayser, 46Erik C Kayser, 50Gary M Kayser, 66Jacquelyn M Kayser, 63Jenna Kayser, 33

Veysel Kayser Phones & Addresses

  • Melrose, MA
  • Malden, MA
  • Cambridge, MA

Work

Company: Mit 2010 Position: Senior research scientist

Education

Degree: PhD School / High School: University of Leeds Specialities: Physical Chemistry

Skills

Biophysics • Fluorescence Spectroscopy • Spectroscopy • Protein Chemistry • Molecular Modeling • Differential Scanning Calorimetry • Microscopy

Industries

Higher Education

Resumes

Resumes

Veysel Kayser Photo 1

Research Engineer At Mit

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Position:
Senior Research Scientist at MIT
Location:
Greater Boston Area
Industry:
Higher Education
Work:
MIT since 2010
Senior Research Scientist
MIT 2006 - 2010
Postdoc
Education:
University of Leeds
PhD, Physical Chemistry
Skills:
Biophysics
Fluorescence Spectroscopy
Spectroscopy
Protein Chemistry
Molecular Modeling
Differential Scanning Calorimetry
Microscopy

Publications

Us Patents

Immunoglobulins With Reduced Aggregation

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US Patent:
20120003211, Jan 5, 2012
Filed:
Jun 19, 2009
Appl. No.:
13/000351
Inventors:
Naresh Chennamsetty - Cambridge MA, US
Bernhard Helk - Basel, CH
Veysel Kayser - Cambridge MA, US
Bernhardt Trout - Cambridge MA, US
Vladimir Voynov - Cambridge MA, US
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
NOVARTIS AG - Base;
International Classification:
A61K 39/395
C12N 5/10
C12N 15/63
C12P 21/00
C07K 16/00
C07H 21/00
US Classification:
4241331, 5303873, 536 2353, 4353201, 435 696, 435328
Abstract:
The present disclosure relates to immunoglobulins with reduced aggregation and compositions, methods of generating such immunoglobulins with computational tools and methods of using such immunoglobulins particularly in the treatment and prevention of disease.

Methods To Identify Macromolecule Binding And Aggregation Prone Regions In Proteins And Uses Therefor

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US Patent:
20110257104, Oct 20, 2011
Filed:
Jun 19, 2009
Appl. No.:
13/000353
Inventors:
Naresh Chennamsetty - Cambridge MA, US
Bernhard Helk - Basel, CH
Bernhardt Trout - Cambridge MA, US
Veysel Kayser - Cambridge MA, US
Vladimir Voynov - Cambridge MA, US
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
NOVARTIS AG - Basel
International Classification:
A61K 38/16
A61P 37/00
G06F 19/00
C07K 14/00
US Classification:
514 212, 530402, 702 19
Abstract:
The present invention provides methods and computational tools based, at least in part, on computer simulations that identify macromolecule binding regions and aggregation prone regions of a protein. Substitutions may then be made in these aggregation prone regions to engineer proteins with enhanced stability and/or a reduced propensity for aggregation. Similarly, substitutions may then be made in these macromolecule binding regions to engineer proteins with altered binding affinity for the macromolecule.

Immunoglobulins With Reduced Aggregation

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US Patent:
20170349650, Dec 7, 2017
Filed:
May 16, 2017
Appl. No.:
15/596867
Inventors:
- Basel, CH
- Cambridge MA, US
Veysel KAYSER - Cambridge MA, US
Bernhardt TROUT - Cambridge MA, US
Vladimir VOYNOV - Cambridge MA, US
Assignee:
Novartis AG - Basel
Massachusetts Institute of Technology - Cambridge MA
International Classification:
C07K 16/18
A61K 39/395
C07K 16/10
Abstract:
The present disclosure relates to immunoglobulins with reduced aggregation and compositions, methods of generating such immunoglobulins with computational tools and methods of using such immunoglobulins particularly in the treatment and prevention of disease.

Methods For Identification Of Sites For Igg Conjugation

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US Patent:
20170198007, Jul 13, 2017
Filed:
Mar 27, 2017
Appl. No.:
15/470576
Inventors:
- Basel, CH
- Cambridge MA, US
Veysel KAYSER - Cambridge MA, US
Bernhardt TROUT - Cambridge MA, US
Vladimir VOYNOV - Cambridge MA, US
Assignee:
Novartis AG - Basel
Massachusetts Institute of Technology - Cambridge MA
International Classification:
C07K 1/13
G01N 33/58
C07K 16/00
A61K 51/10
A61K 49/00
Abstract:
The present disclosure relates to immunoglobulins and immunoglobulin conjugates with reduced oligomerization and efficient labeling and compositions, methods of generating such immunoglobulins and immunoglobulin conjugates and methods of using such immunoglobulin conjugates particularly in the treatment and prevention of disease.

Methods To Identify Macromolecule Binding And Aggregation Prone Regions In Proteins And Uses Therefor

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US Patent:
20160364521, Dec 15, 2016
Filed:
Aug 26, 2016
Appl. No.:
15/249161
Inventors:
- Basel, CH
- Cambridge MA, US
Bernhardt TROUT - Cambridge MA, US
Veysel KAYSER - Cambridge MA, US
Vladimir VOYNOV - Cambridge MA, US
Assignee:
Novartis AG - Basel
Massachusetts Institute of Technology - Cambridge MA
International Classification:
G06F 19/16
C07K 14/71
C07K 16/00
Abstract:
The present invention provides methods and computational tools based, at least in part, on computer simulations that identify macromolecule binding regions and aggregation prone regions of a protein. Substitutions may then be made in these aggregation prone regions to engineer proteins with enhanced stability and/or a reduced propensity for aggregation. Similarly, substitutions may then be made in these macromolecule binding regions to engineer proteins with altered binding affinity for the macromolecule.

Methods For Identification Of Sites For Igg Conjugation

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US Patent:
20150056220, Feb 26, 2015
Filed:
Aug 1, 2014
Appl. No.:
14/449975
Inventors:
- Basel, CH
- Cambridge MA, US
Veysel KAYSER - Cambridge MA, US
Bernhardt TROUT - Cambridge MA, US
Vladimir VOYNOV - Cambridge MA, US
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
NOVARTIS AG - Basel
International Classification:
A61K 47/48
US Classification:
4241781, 4353201, 435 696, 5303911, 536 2353, 5303917, 5303913, 435188, 4352523, 435328
Abstract:
The present disclosure relates to immunoglobulins and immunoglobulin conjugates with reduced oligomerization and efficient labeling and compositions, methods of generating such immunoglobulins and immunoglobulin conjugates and methods of using such immunoglobulin conjugates particularly in the treatment and prevention of disease.

Immunoglobulins With Reduced Aggregation

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US Patent:
20140348820, Nov 27, 2014
Filed:
Apr 29, 2014
Appl. No.:
14/265149
Inventors:
- Basel, CH
- Cambridge MA, US
Veysel KAYSER - Cambridge MA, US
Bernhardt TROUT - Cambridge MA, US
Vladimir VOYNOV - Cambridge MA, US
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
NOVARTIS AG - Basel
International Classification:
C07K 16/18
US Classification:
4241331, 5303873, 536 2353, 435 696, 4353201, 435328
Abstract:
The present disclosure relates to immunoglobulins with reduced aggregation and compositions, methods of generating such immunoglobulins with computational tools and methods of using such immunoglobulins particularly in the treatment and prevention of disease.
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Veysel Kayser from Melrose, MA, age ~52 Get Report