US Patent:
20090053292, Feb 26, 2009
Inventors:
Kenneth Tucker - Frederick MD, US
Ulrich F. Tillmann - Mount Laurel NJ, US
International Classification:
A61K 9/127
C07K 14/195
C12N 1/20
G01N 33/543
C12Q 1/68
C07K 16/12
A61K 39/02
US Classification:
424450, 530350, 530324, 4241901, 4352521, 5303895, 435 732, 435 6
Abstract:
The invention discloses the outer membrane protein polypeptide and polypeptides derived therefrom (collectively “OMP21”), nucleotide sequences encoding said OMP21, and antibodies that specifically bind OMP21. Also disclosed are pharmaceutical compositions including prophylactic or therapeutic compositions, which may be immunogenic compositions including vaccines, comprising OMP21, antibodies thereto or nucleotides encoding same. The invention additionally discloses methods of inducing an immune response to and OMP21 in an animal, preferably a human, methods of treating and methods of diagnosing infections in an animal, preferably a human, and kits therefor.