US Patent:
20140134191, May 15, 2014
Inventors:
John A. Weidanz - Abilene TX, US
Ulrich Bickel - Amarillo TX, US
Assignee:
TEXAS TECH UNIVERSITY SYSTEM - Lubbock TX
International Classification:
A61K 39/395
Abstract:
The present invention includes a method of delivering a therapeutic agent into and across an endothelial cell (EC) in a subject in need thereof, comprising: attaching to a T Cell receptor mimic (TCR mimic) an active agent to form a therapeutic agent; and administering to the subject the therapeutic agent in a pharmaceutically acceptable carrier, wherein the therapeutic agent effectively crosses the EC microvascular barrier. Furthermore, the present invention relates to methods of treating diseases (particularly neuronal diseases) or conditions comprising identifying a subject in need of such a treatment and administering to said subject a composition comprising a TCR mimic conjugated to an active agent.