Thea E Lubrecht

6595961, Jul 22, 2003

Apr 16, 2001

09/835446

Kevin George Hetzler - Sparta NJ
Thea Lubrecht - Randolph NJ

Becton, Dickinson and Company - Franklin Lakes NJ

A61M 500

604181, 604187

A medical transfer or storage device for delivery or storage of a medicament, drug or vaccine, wherein a first component, preferably the major component, is formed of a cyclic olefin polymer, and a second component in contact with the first component is formed of a second polymer which does not chemically interact with the cyclic olefin polymeric component at elevated temperatures, including sterilization. More specifically, the relative energy distance Ra/Ro of the polymer selected for the second component relative to the cyclic olefin polymer is greater than 0. 75 and the molecular weight of the second polymer is at least 5,000 to prevent adhesion of the second component to the cyclic olefin component and stress cracking at elevated temperatures. The most preferred embodiment is a syringe assembly having a cyclic olefin polymeric barrel and a resilient stopper formed of the second polymer.

6663601, Dec 16, 2003

Jun 5, 2003

10/454993

Kevin George Hetzler - Sparta NJ
Thea Lubrecht - Randolph NJ

Becton Dickinson and Company - Franklin Lakes NJ

A61M 500

604181, 604187, 264238

A medical transfer or storage device for delivery or storage of a medicament, drug or vaccine, wherein a first component, preferably the major component, is formed of a cyclic olefin polymer, and a second component in contact with the first component is formed of a second polymer which does not chemically interact with the cyclic olefin polymeric component at elevated temperatures, including sterilization. More specifically, the relative energy distance Ra/Ro of the polymer selected for the second component relative to the cyclic olefin polymer is greater than 0. 75 and the molecular weight of the second polymer is at least 5,000 to prevent adhesion of the second component to the cyclic olefin component and stress cracking at elevated temperatures. The most preferred embodiment is a syringe assembly having a cyclic olefin polymeric barrel and a resilient stopper formed of the second polymer.

6746430, Jun 8, 2004

Dec 19, 2000

09/740576

Thea E. Lubrecht - Randolph NJ

Becton, Dickinson and Company - Franklin Lakes NJ

A61M 5315

604230, 604222, 604232, 427487

A method for lubricating a sealing member and a medicament chamber in a drug delivery device includes providing lubricating silicone on the surface of the stopper and within the plastic material of the chamber. The stopper preferably is first washed and rinsed in hot deionized water followed by drying. The dried sealing member is then tumbled with polymeric silicone and then irradiated at a target dose between 2. 5 to 4. 0 Mrads to cause the silicone molecules to bond with the elastomeric material of the stopper. The irradiated sealing members are then loaded in any of a series of chambers including syringes, pre-filled syringes, drug cartridges, and needleless injector ampules. The chamber preferably is made from a plastic material that has been mixed with a lubricating solution such as silicone when the plastic is compounded.

7141042, Nov 28, 2006

Dec 14, 2000

09/737047

Thea E. Lubrecht - Randolph NJ, US

Becton Dickinson and Company - Franklin Lakes NJ

A61M 5/315

604230

A method for lubricating a sealing member in a drug delivery device includes the steps of washing and rinsing the sealing members in hot deionized water following by drying the sealing members. The dried sealing members are tumbled with polymeric silicone and then irradiated at a target dose between 2. 5 and 4. 0 Mrads. The irradiated sealing members are then utilized in a variety of drug delivery devices including syringes, pre-filed syringes, drug cartridges, and needleless injector ampules.

7198685, Apr 3, 2007

Feb 12, 2003

10/365026

Kevin George Hetzler - Sparta NJ, US
Thea Lubrecht - Randolph NJ, US
Roger William Groskopf - Saddle Brook NJ, US

Becton, Dickinson and Company - Franklin Lakes NJ

B32B 37/00
B65B 65/00

156 69, 1563082, 1563084, 215232, 215246, 215247, 215316, 220213

A method of fusing a component to a sterilized storage or delivery device formed of a cyclic olefin polymer which includes forming the storage or delivery device from a cyclic olefin polymer, forming a second member or component having at least a surface layer formed of the second polymer, wherein the Hansen relative energy distance Ra/Ro of the second polymer relative to the cyclic olefin polymer is equal to or less than 0. 7, applying the second member to the storage or delivery device, and heating the assembly to the sterilization temperature, thereby causing the second polymer to chemically interact with the cyclic olefin polymer, fusing the second component to the storage or delivery device. The preferred embodiment of the invention is a medical container, such as a vial, wherein the vial is formed of a cyclic olefin polymer and the cap, closure or collar is formed of a second polymer heat fused to the vial or container.

7297216, Nov 20, 2007

Feb 12, 2003

10/365013

Kevin George Hetzler - Sparta NJ, US
Thea Lubrecht - Randolph NJ, US
Roger William Groskopf - Saddle Brook NJ, US

Becton, Dickinson and Company - Franklin Lakes NJ

B32B 37/00
B65B 65/00

156 69, 1563082, 1563084, 215232, 215246, 215247, 215316, 220213

A method of fusing a component to a sterilized storage or delivery device formed of a cyclic olefin polymer which includes forming the storage or delivery device from a cyclic olefin polymer, forming a second member or component having at least a surface layer formed of the second polymer, wherein the Hansen relative energy distance Ra/Ro of the second polymer relative to the cyclic olefin polymer is equal to or less than 0. 7, applying the second member to the storage or delivery device, and heating the assembly to the sterilization temperature, thereby causing the second polymer to chemically interact with the cyclic olefin polymer, fusing the second component to the storage or delivery device. The preferred embodiment of the invention is a medical container, such as a vial, wherein the vial is formed of a cyclic olefin polymer and the cap, closure or collar is formed of a second polymer heat fused to the vial or container.

7615271, Nov 10, 2009

Feb 11, 2003

10/364629

Kevin George Hetzler - Sparta NJ, US
Thea Lubrecht - Randolph NJ, US
Roger William Groskopf - Saddle Brook NJ, US

Becton, Dickinson and Company - Franklin Lakes NJ

B32B 27/08
B29C 47/00
B65D 39/00
H01H 29/02
H01H 29/20

428 357, 428 368, 428 369, 215200, 215232

A method of fusing a component to a sterilized storage or delivery device formed of a cyclic olefin polymer which includes forming the storage or delivery device from a cyclic olefin polymer, forming a second member or component having at least a surface layer formed of the second polymer, wherein the Hansen relative energy distance Ra/Ro of the second polymer relative to the cyclic olefin polymer is equal to or less than 0. 7, applying the second member to the storage or delivery device, and heating the assembly to the sterilization temperature, thereby causing the second polymer to chemically interact with the cyclic olefin polymer, fusing the second component to the storage or delivery device. The preferred embodiment of the invention is a medical container, such as a vial, wherein the vial is formed of a cyclic olefin polymer and the cap, closure or collar is formed of a second polymer heat fused to the vial or container.

20020150709, Oct 17, 2002

Apr 16, 2001

09/835754

Kevin Hetzler - Sparta NJ, US
Thea Lubrecht - Randolph NJ, US
Roger Groskopf - Saddle Brook NJ, US

B32B001/02
B65D001/00
F16L001/00
B32B001/08
B29D022/00
B29D023/00
B23K001/20
B23K031/02

428/035700, 228/211000

A method of fusing a component to a sterilized storage or delivery device formed of a cyclic olefin polymer which includes forming the storage or delivery device from a cyclic olefin polymer, forming a second member or component having at least a surface layer formed of the second polymer, wherein the Hansen relative energy distance Ra/Ro of the second polymer relative to the cyclic olefin polymer is equal to or less than 0.7, applying the second member to the storage or delivery device, and heating the assembly to the sterilization temperature, thereby causing the second polymer to chemically interact with the cyclic olefin polymer, fusing the second component to the storage or delivery device. The preferred embodiment of the invention is a medical container, such as a vial, wherein the vial is formed of a cyclic olefin polymer and the cap, closure or collar is formed of a second polymer heat fused to the vial or container.