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Tal Teitz Phones & Addresses

  • Omaha, NE
  • Memphis, TN
  • Cordova, TN
  • New York, NY
  • 1180 Oak River Rd, Memphis, TN 38120

Publications

Us Patents

Tumor Suppressor Protein Involved In Death Signaling, And Diagnostics, Therapeutics, And Screening Based On This Protein

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US Patent:
7052834, May 30, 2006
Filed:
Dec 30, 1999
Appl. No.:
09/477082
Inventors:
Vincent J. Kidd - Memphis TN, US
Jill M. Lahti - Memphis TN, US
Tal Teitz - Cordova TN, US
Assignee:
St. Jude Children's Research Hospital - Memphis TN
International Classification:
C12Q 1/68
C07H 21/04
US Classification:
435 6, 435 4, 436 63, 436 64, 536 241, 536 243, 536 2431, 536 2433
Abstract:
The present invention relates to identification of tumor suppressor activity of a protein, caspase-8 (CASP8), and to related diagnostic and therapeutic compositions and methods. The discovery of this tumor suppressor activity provides screening targets as well, particularly screening for compounds that overcome gene inactivation that results from genomic methylation of the promoter. In particular, CASP8 is functionally inactivated in greater than 90% of all MYCN amplified neuroblastoma cell lines analyzed. Inactivation of CASP8 was observed to occur by homozygous deletion, heterozygous deletion coupled with gene silencing by methylation, and homozygous gene silencing by methylation. A PCR methylation analysis for inactivation of CASP8 is described.

Methods And Compositions For The Prevention And Treatment Of Hearing Loss

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US Patent:
20220265660, Aug 25, 2022
Filed:
May 4, 2022
Appl. No.:
17/736330
Inventors:
- Omaha NE, US
Tal Teitz - Omaha NE, US
Assignee:
Ting Therapeutics LLC - Omaha NE
International Classification:
A61K 31/519
A61P 27/16
A61K 31/437
A61K 31/4439
A61K 31/4709
A61K 31/506
Abstract:
Method, kit and pharmaceutical compositions using an inhibitor of EGFR signaling for prevention or treatment of hearing loss are described.

Methods And Compositions For The Prevention And Treatment Of Hearing Loss

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US Patent:
20230000881, Jan 5, 2023
Filed:
Jul 12, 2022
Appl. No.:
17/862656
Inventors:
- Memphis TN, US
Tal Teitz - Omaha NE, US
Fang Jie - Memphis TN, US
Goktug Asli - Memphis TN, US
Min Jaeki - Memphis TN, US
R. Kiplin Guy - Memphis TN, US
Assignee:
St. Jude Children's Research Hospital - Memphis TN
International Classification:
A61K 31/55
A61K 31/404
A61K 31/454
A61K 31/506
A61K 31/52
A61K 31/519
A61K 31/4155
A61K 31/4015
A61P 27/16
Abstract:
In one aspect, pharmaceutical compositions comprising a CDK2 inhibitor and one or more of at least one agent known to treat a hearing impairment and at least one agent known to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Methods And Compositions For The Prevention And Treatment Of Hearing Loss

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US Patent:
20200179397, Jun 11, 2020
Filed:
Dec 9, 2019
Appl. No.:
16/707991
Inventors:
- Memphis TN, US
Tal Teitz - Memphis TN, US
Jie Fang - Memphis TN, US
Asli Goktug - Memphis TN, US
Taosheng Chen - Germantown TN, US
Jaeki Min - Memphis TN, US
R. Kiplin Guy - Memphis TN, US
International Classification:
A61K 31/55
A61K 31/404
A61K 31/454
A61K 31/506
A61K 31/52
A61P 27/16
Abstract:
In one aspect, pharmaceutical compositions comprising a CDK2 inhibitor and one or more of at least one agent known to treat a hearing impairment and at least one agent known to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Compositions And Methods For Prevention And Treatment Of Hearing Loss

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US Patent:
20200093923, Mar 26, 2020
Filed:
Apr 30, 2018
Appl. No.:
16/610170
Inventors:
- Memphis TN, US
Fei Zheng - Memphis TN, US
Tetsuji Yamashita - Memphis TN, US
Zoe Kellard - West Sussex, GB
Tal Teitz - Omaha NE, US
Jaeki Min - Memphis TN, US
Taosheng Chen - Germantown TN, US
Assignee:
ST. JUDE CHILDREN'S RESEARCH HOSPITALEINDHOVEN - Memphis TN
International Classification:
A61K 39/395
A61K 31/713
A61K 45/06
A61P 27/16
A61K 31/517
A61K 31/44
A61K 31/5377
A61K 31/18
A61K 31/58
A61K 31/519
A61K 31/422
A61K 31/506
A61K 31/4709
A61K 31/4706
A61K 38/17
Abstract:
Methods and compositions using an inhibitor of EGFR signaling for prevention or an inhibitor of EGFR signaling and a nucleic acid molecule encoding an atonal-associated factor for treatment of hearing loss are described.
Tal Teitz from Omaha, NE, age ~64 Get Report