US Patent:
20100048650, Feb 25, 2010
Inventors:
Ira S. Cohen - Stony Brook NY, US
Zhongju Lu - Port Jefferson Station NY, US
Irvin Krukenkamp - South Berwick ME, US
Peter R. Brink - Setauket NY, US
Richard B. Robinson - Cresskill NJ, US
Steven J. Feinmark - Haworth NJ, US
International Classification:
A61K 31/426
A61K 31/23
A61K 31/40
A61K 31/216
C12N 5/00
G01N 33/53
C12Q 1/02
A61P 9/00
US Classification:
514367, 514552, 514425, 514532, 435375, 436501, 435 29
Abstract:
The present invention relates to methods and compositions for modulating the activity of two-pore domain K+ channels (“K2P channels”) as a means for inducing preconditioning protection. Such preconditioning can be used to reduce the effect of ischemia associated with ischemic heart disease, myocardial infarcation or cardiac surgery. The invention is based on the discovery that the myoprotective current induced by short periods of ischemia is carried by a non-classical two-pore domain K+ channel.