Inventors:
David J. Madar - Gurnee IL, US
Stevan W. Djuric - Libertyville IL, US
Melissa J. Michmerhuizen - Gurnee IL, US
Hana A. Kopecka - Vernon Hills IL, US
Xiaofeng Li - Gurnee IL, US
Kenton L. Longenecker - Grayslake IL, US
Zhonghua Pei - Libertyville IL, US
Daisy Pireh - Lake Forest IL, US
Hing L. Sham - Vernon Hills IL, US
Kent D. Stewart - Gurnee IL, US
Bruce G. Szczepankiewicz - Wildwood IL, US
Paul E. Wiedeman - Deerfield IL, US
Hong Yong - Grayslake IL, US
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
A61K 31/40
A61K 31/401
A61K 31/454
A61K 31/4545
A61K 31/506
C07D 405/12
C07D 401/12
C07D 211/58
C07D 239/42
US Classification:
514422, 514326, 514318, 514275, 544331, 546193, 546208, 548517
Abstract:
The present invention relates to compounds that inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.