US Patent:
20080125397, May 29, 2008
Inventors:
Stella K. Lui - Pacifica CA, US
Wenli Ma - Mountain View CA, US
Robert M. Yee - San Francisco CA, US
International Classification:
A61K 31/675
A61P 35/04
C07F 9/06
Abstract:
2-({2-Oxo-2-[(pyridin-3-ylmethyl)amino]ethyl}sulfonyl)ethyl N,N,N′,N′-tetrakis(2-chloroethyl)phosphorodiamidate and its acid addition salts, especially in solid form, their preparation and intermediates in their preparation, formulations containing them, and methods of treatment using them. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.