Inventors:
- Tokyo, JP
Silvia BUONAMICI - Boston MA, US
Thiwanka SAMARAKOON - Westwood MA, US
Sudeep PRAJAPATI - Somerville MA, US
Nathan FISHKIN - Weymouth MA, US
James PALACINO - Wellesley MA, US
Michael SEILER - Belmont MA, US
Ping ZHU - Acton MA, US
Andrew COOK - Stow MA, US
Peter SMITH - Arlington MA, US
Xiang LIU - Winchester MA, US
Shelby ELLERY - Boston MA, US
Dominic REYNOLDS - Stoneham MA, US
Lihua YU - Acton MA, US
Zhenhua WU - Belmont MA, US
Shouyong PENG - Belmont MA, US
Nicholas CALANDRA - Boston MA, US
Megan SHEEHAN - Allston MA, US
Yonghong XIAO - Belmont MA, US
International Classification:
C07D 405/12
A61P 35/00
Abstract:
Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.
