US Patent:
20040229843, Nov 18, 2004
Inventors:
Bryan Toole - Mt. Pleasant SC, US
Suniti Misra - Mount Pleasant SC, US
Shibnath Ghatak - Mount Pleasant SC, US
International Classification:
A61K031/728
Abstract:
Pharmaceutical compositions and methods for sensitizing multi-drug resistant cancer or radiation resistant cancer cells to chemotherapeutic agents are provided. Compositions include ligands of hyaluronan receptors, including glycosaminoglycans such as hyaluronan oligomers and derivatives of these oligomers, hyaluronan binding proteins, antibodies specific for hyaluronan receptors, hyaluronan mimetics, inhibitors of hyaluronan synthesis, and stimulators of hyaluronan degradation.