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Sebastian Maerkl Phones & Addresses

  • Palo Alto, CA
  • Pasadena, CA

Publications

Us Patents

Mechanically Induced Trapping Of Molecular Interactions

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US Patent:
8039269, Oct 18, 2011
Filed:
Jan 26, 2007
Appl. No.:
11/698757
Inventors:
Sebastian J. Maerkl - Palo Alto CA, US
Stephen R. Quake - Stanford CA, US
Assignee:
California Institute of Technology - Pasadena CA
International Classification:
G01N 33/543
US Classification:
436518
Abstract:
The invention provides devices and methods for surface patterning the substrate of a microfluidic device, and for detection and analysis of interactions between molecules by mechanically trapping a molecular complex while substantially expelling solvent and unbound solute molecules. Examples of molecular complexes include protein-protein complexes and protein-nucleic acid complexes.

Microfluidic Large Scale Integration

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US Patent:
8220494, Jul 17, 2012
Filed:
Aug 10, 2004
Appl. No.:
10/915960
Inventors:
Vincent Studer - Paris, FR
Stephen R. Quake - San Marino CA, US
W. French Anderson - San Marino CA, US
Sebastian J. Maerkl - Pasadena CA, US
Assignee:
California Institute of Technology - Pasadena CA
International Classification:
F15C 1/06
US Classification:
137833, 251 611
Abstract:
Using basic physical arguments, a design and method for the fabrication of microfluidic valves using multilayer soft lithography is presented. Embodiments of valves in accordance with the present invention feature elastomer membrane portions of substantially constant thickness, allowing the membranes to experience similar resistance to an applied pressure across their entire width. Such on-off valves fabricated with upwardly- or downwardly-deflectable membranes can have extremely low actuation pressures, and can be used to implement active functions such as pumps and mixers in integrated microfluidic chips. Valve performance was characterized by measuring both the actuation pressure and flow resistance over a wide range of design parameters, and comparing them to both finite element simulations and alternative valve geometries.

Microfluidic Large Scale Integration

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US Patent:
20040112442, Jun 17, 2004
Filed:
Sep 24, 2003
Appl. No.:
10/670997
Inventors:
Sebastian Maerkl - Pasadena CA, US
Todd Thorsen - Arlington MA, US
Xiaoyan Bao - Pasadena CA, US
Stephen Quake - San Marino CA, US
Vincent Studer - Paris, FR
Assignee:
California Institute of Technology - Pasadena CA
International Classification:
F16K011/20
US Classification:
137/597000
Abstract:
High-density microfluidic chips contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large scale integration (LSI). A component of these networks is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. These integrated microfluidic networks can be used to construct a variety of highly complex microfluidic devices, for example the microfluidic analog of a comparator array, and a microfluidic memory storage device resembling electronic random access memories.

Programming Microfluidic Devices With Molecular Information

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US Patent:
20070248971, Oct 25, 2007
Filed:
Jan 26, 2007
Appl. No.:
11/698802
Inventors:
Sebastian Maerkl - Palo Alto CA, US
Stephen Quake - Stanford CA, US
Assignee:
California Institute of Technology - Pasadena CA
International Classification:
G01N 33/00
B01L 11/00
B29C 65/48
C12Q 1/68
US Classification:
435006000, 156060000, 422099000, 435041000, 436086000
Abstract:
The invention provides a microfluidic device having a plurality of chambers each containing separately deposited reagents. The invention also provides an efficient PCR-based method for producing a linear expression template. The invention also provides methods for analyzing interactions between molecules, involving flow-deposition of expression templates on the substrate of chambers in a microfluidic device, and expressing proteins from the templates.

Microfluidic Large Scale Integration

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US Patent:
20080029169, Feb 7, 2008
Filed:
Aug 8, 2006
Appl. No.:
11/463241
Inventors:
Sebastian J. Maerkl - Pasadena CA, US
Todd A. Thorsen - Arlington MA, US
Xiaoyan Bao - Pasadena CA, US
Stephen R. Quake - San Marino CA, US
Vincent Studer - Paris, FR
Assignee:
California Institute of Technology - Pasadena CA
International Classification:
F16K 11/20
US Classification:
137597
Abstract:
High-density microfluidic chips contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large scale integration (LSI). A component of these networks is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. These integrated microfluidic networks can be used to construct a variety of highly complex microfluidic devices, for example the microfluidic analog of a comparator array, and a microfluidic memory storage device resembling electronic random access memories.

Microfluidic Large Scale Integration

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US Patent:
20100154890, Jun 24, 2010
Filed:
Oct 12, 2009
Appl. No.:
12/577689
Inventors:
Sebastian J. Maerkl - Pasadena CA, US
Todd A. Thorsen - Arlington MA, US
Xiaoyan Bao - Pasadena CA, US
Stephen R. Quake - San Marino CA, US
Vincent Studer - Paris, FR
Assignee:
California Institute of Technology - Pasadena CA
International Classification:
F15C 3/00
G05D 7/00
G05D 11/00
US Classification:
137 1, 137 3, 137833, 137597
Abstract:
High-density microfluidic chips contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large scale integration (LSI). A component of these networks is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. These integrated microfluidic networks can be used to construct a variety of highly complex microfluidic devices, for example the microfluidic analog of a comparator array, and a microfluidic memory storage device resembling electronic random access memories.

Mechanically Induced Trapping Of Molecular Interactions

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US Patent:
20120129719, May 24, 2012
Filed:
Oct 6, 2011
Appl. No.:
13/317063
Inventors:
Stephen R. Quake - Stanford CA, US
Sebastian J. Maerkl - Palo Alto CA, US
Assignee:
California Institute of Technology - Pasadena CA
International Classification:
C40B 30/04
C40B 60/12
C40B 50/00
US Classification:
506 9, 506 23, 506 39
Abstract:
The invention provides devices and methods for surface patterning the substrate of a microfluidic device, and for detection and analysis of interactions between molecules by mechanically trapping a molecular complex while substantially expelling solvent and unbound solute molecules. Examples of molecular complexes include protein-protein complexes and protein-nucleic acid complexes.
Sebastian J Maerkl from Palo Alto, CA, age ~45 Get Report