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Ross L Cagan

from Alexandria, VA
Age ~64
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Also known as:
Ross Yumi Cagan, Leigh Cagan Ross
Related to:
Carol A Ross, 88Carol K Ross, 71Jazz K Cagan, 28A W Goldstein, 62David CaganYumi Kasai, 63Maya K Cagan, 32Maya Kasai CaganMyrna A Roth, 92Stephen Weiss, 61Jonathan Ross, 62Robert B Roth, 98Elizabeth S Weiss, 57
Connected to:
Diane S Cagan, 86Josiah Cagan, 33Leslie Cagan, 77Myron R Cagan, 74Paul H Cagan, 86Shauna T Cagan, 51Shaunte L Cagan, 45Tod S Cagan, 54Christopher C Cagang, 50Okan Cagar, 59

Ross Cagan Phones & Addresses

  • Alexandria, VA
  • 460 79Th St, New York, NY 10001 (212) 327-0561
  • 460 E 79Th St APT 20B, New York, NY 10075 (212) 327-0561
  • 340 64Th St, New York, NY 10021 (212) 327-0561
  • 427 Oakley Dr, Saint Louis, MO 63105 (314) 725-6849
  • 660 Euclid Ave, Saint Louis, MO 63110
  • Clayton, MO

Work

Company: Icahn school of medicine at mount sinai 2007 Position: Professor and associate dean

Education

Degree: Bachelor of Arts (B.A.) School / High School: University of Chicago 1978 to 1982 Specialities: Biology

Industries

Biotechnology

Resumes

Resumes

Ross Cagan Photo 1

Professor And Associate Dean, Mount Sinai

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Position:
Professor and Associate Dean at Icahn School of Medicine at Mount Sinai, Director at Center for Personalized Cancer Therapeutics, Editor-in-Chief at Disease Models and Mechanisms, journal, Co-Founder at Medros
Location:
United States
Industry:
Biotechnology
Work:
Icahn School of Medicine at Mount Sinai since 2007
Professor and Associate Dean
Center for Personalized Cancer Therapeutics - Icahn School of Medicine at Mount Sinai since 2007
Director
Disease Models and Mechanisms, journal since Jan 2013
Editor-in-Chief
Medros since Jan 2006
Co-Founder
Washington University School of Medicine - Greater St. Louis Area Sep 1993 - Jul 2007
Professor
Education:
University of Chicago 1978 - 1982
Bachelor of Arts (B.A.), Biology Princeton University 1984 - 1989
Doctor of Philosophy (Ph.D.), Biology/Biological Sciences, General UCLA 1989 - 1993
Postdoctoral fellow, Developmental Biology and Embryology

Publications

Us Patents

High Throughput Pharmaceutical Screening Using Drosophila

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US Patent:
20050260135, Nov 24, 2005
Filed:
Jan 14, 2005
Appl. No.:
11/036897
Inventors:
Thomas Baranski - Kirkwood MO, US
Ross Cagan - Clayton MO, US
International Classification:
A61K049/00
US Classification:
424009200
Abstract:
High throughput drug screening assay methods and related apparatus are described. Wild-type are raised in multi-well microtiter plates on a growth medium having a high level of a sugar such as glucose. The high sugar diet during development induces screenably distinct characteristics in the wild-type . Compounds that putatively modify the screenably distinct characteristic are tested by feeding to the embryos, and determining whether the compound modifies the screenably distinct characteristic induced by the high sugar growth medium. The assay methods and related articles of composition can also be used to assay toxicity of candidate compounds.

High Throughput Cancer Pharmaceutical Screening Using Drosophila

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US Patent:
20060010505, Jan 12, 2006
Filed:
Jun 16, 2005
Appl. No.:
11/154035
Inventors:
Thomas Baranski - Kirkwood MO, US
Ross Cagan - Clayton MO, US
International Classification:
A01K 67/033
US Classification:
800010000, 800013000
Abstract:
High throughput drug screening assay methods and related apparatus are described. with screenably distinct characteristics are raised in multi-well microtiter plates on standard growth medium. Screenably distinct characteristics which mimic human cancer or cancer-related condition are established by modifying expression of an oncogene or tumor suppressor in the . Compounds that putatively modify the screenably distinct characteristic are then tested by feeding the compounds to the embryos, and determining whether the compound modifies the screenably distinct characteristic induced by modifying gene expression. The assay methods and related articles of composition can also be used to simultaneously assay toxicity of candidate compounds.

High Throughput Screening Methods For Anti-Metastatic Compounds

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US Patent:
20060156421, Jul 13, 2006
Filed:
Dec 30, 2005
Appl. No.:
11/323151
Inventors:
Ross Cagan - Clayton MO, US
International Classification:
A01K 67/033
US Classification:
800003000, 800013000
Abstract:
High throughput methods for screening of anti-cancer compounds using are described. The methods involve modifying the expression of dCsk and observing the effect of putative anti-cancer candidate compounds on resulting expressed characteristics in the . Related animal models and apparatus are also provided.

Kinase Inhibitor Compounds, Compositions, And Methods Of Treating Cancer

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US Patent:
20200325103, Oct 15, 2020
Filed:
Nov 14, 2019
Appl. No.:
16/684159
Inventors:
- New York NY, US
Ross L. CAGAN - New York NY, US
Alex P. SCOPTON - New York NY, US
International Classification:
C07D 213/81
A61P 35/00
Abstract:
The present invention relates to a compound having the structure of formula (I) or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where X, Y, Z, R, R, R, R, R, R, and Rare as described herein. The present invention also relates to compositions containing the compound having the structure of formula (I), and a method of treating cancer in a subject.

Kinase Inhibitor Compounds, Compositions, And Methods Of Treating Cancer

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US Patent:
20190202789, Jul 4, 2019
Filed:
Aug 17, 2017
Appl. No.:
16/325218
Inventors:
- New York NY, US
Ross L. CAGAN - New York NY, US
Alex P. SCOPTON - New York NY, US
Assignee:
Ichan School of Medicine at Mount Sinal - New York NY
International Classification:
C07D 213/81
A61P 35/00
Abstract:
The present invention relates to a compound having the structure of formula (I) or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where X, Y, Z, R, R, R, R, R, R, and Rare as described herein. The present invention also relates to compositions containing the compound having the structure of formula (I), and a method of treating cancer in a subject.

Substituted Pyrazolo[3,4-D]Pyrimidines And Uses Thereof

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US Patent:
20160354377, Dec 8, 2016
Filed:
Mar 23, 2016
Appl. No.:
15/078657
Inventors:
- Oakland CA, US
- New York NY, US
Martin Sos - San Francisco CA, US
Trever G. Bivona - San Francisco CA, US
Kevan M. Shokat - San Francisco CA, US
Ross L. Cagan - New York NY, US
International Classification:
A61K 31/519
A61K 45/06
Abstract:
Presented herein are novel therapeutic compounds and methods of using the same for the treatment of cancers.

Therapeutic Methods For Treating Solid Tumors And Related Diagnostic Methods

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US Patent:
20160022757, Jan 28, 2016
Filed:
Mar 14, 2014
Appl. No.:
14/775472
Inventors:
Erdem BANGI - New York NY, US
Ross CAGAN - New York NY, US
Assignee:
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI - New York NY
International Classification:
A61K 38/05
A61K 31/519
G01N 33/574
A61K 31/416
A61K 31/7088
A61K 45/06
A61K 31/4745
A61K 31/5377
Abstract:
The present invention provides a method for treating a subject afflicted with a cancer which comprises administering to the subject (i) a proteasome antagonist and (ii) a PI3K signal transduction pathway antagonist, each of (i) and (ii) in an amount such that when both (i) and (ii) are administered, the administration is effective to treat the subject. The present invention also provides a method for treating a subject afflicted with a cancer which comprises administering to the subject (i) a proteasome antagonist, and (ii) an oligonucleotide which decreases the amount of PI3K, mTor, TORC1, TORC2, AKT, or JNK produced by cells of the cancer. The present invention provides processes for identifying whether a compound is an epithelial cancer drug candidate. The present invention also provides a method for identifying a cancer patient who will likely benefit from treatment with a PI3K signal transduction pathway antagonist.

Substituted Pyrazolo[3,4-D]Pyrimidines And Uses Thereof

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US Patent:
20140243357, Aug 28, 2014
Filed:
Feb 25, 2014
Appl. No.:
14/189742
Inventors:
- New York NY, US
- Oakland CA, US
Martin Sos - San Francisco CA, US
Trever G. Bivona - San Francisco CA, US
Kevan M. Shokat - San Francisco CA, US
Ross L. Cagan - New York NY, US
Assignee:
Mount Sinai School of Medicine - New York NY
The Regents of the University of California - Oakland CA
International Classification:
C07D 487/04
A61K 31/519
US Classification:
5142621, 544262
Abstract:
Presented herein are novel therapeutic compounds and methods of using the same for the treatment of cancers.
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Ross L Cagan from Alexandria, VA, age ~64 Get Report